| Literature DB >> 12688968 |
A Gamba1, D Ambrosi, A Coniglio, A de Candia, S Di Talia, E Giraudo, G Serini, L Preziosi, F Bussolino.
Abstract
Experiments of in vitro formation of blood vessels show that cells randomly spread on a gel matrix autonomously organize to form a connected vascular network. We propose a simple model which reproduces many features of the biological system. We show that both the model and the real system exhibit a fractal behavior at small scales, due to the process of migration and dynamical aggregation, followed at large scale by a random percolation behavior due to the coalescence of aggregates. The results are in good agreement with the analysis performed on the experimental data.Mesh:
Year: 2003 PMID: 12688968 DOI: 10.1103/PhysRevLett.90.118101
Source DB: PubMed Journal: Phys Rev Lett ISSN: 0031-9007 Impact factor: 9.161