| Literature DB >> 12688363 |
César Paz-Y-Miño, Melissa Arévalo, Paola E Leone.
Abstract
The role of BCR/ABL isoforms and their relationships to leukemia phenotype are discussed continuously because of the variety of information reported. Here we describe a man with CML an atypical b3/a3 rearrangement, who had a good response to INFalpha treatment. This may be due to a deletion of the ABL exon 2 sequences, which are an essential part of the ABL SH3 domain inducing STAT5 expression, which is indeed crucial for the BCR/ABL leukemogenesis; because of its role in anti-apoptotic activity and cell cycle progress.Entities:
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Year: 2003 PMID： 12688363 DOI： 10.1080/1042819021000029678
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022