| Literature DB >> 12687406 |
T Hanada1, I Kinjyo, K Inagaki-Ohara, A Yoshimura.
Abstract
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. These cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in inflammatory diseases. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.Entities:
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Year: 2003 PMID： 12687406 DOI： 10.1007/s10254-003-0015-z
Source DB: PubMed Journal: Rev Physiol Biochem Pharmacol ISSN： 0303-4240 Impact factor: 5.545