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Literature DB >> 12687354

Expression of CD83 in the murine immune system.

Matthias Wolenski¹, Sven O Cramer, Svenja Ehrlich, Christiane Steeg, Gudrun Grossschupff, Klara Tenner-Racz, Paul Racz, Bernhard Fleischer, Arne von Bonin.

Abstract

CD83 is used as a marker for mature dendritic cells (DC) in man. We have developed a new monoclonal antibody (mAb), Michel-17, that specifically recognizes mouse CD83. We show that murine CD83 is expressed mainly on mature DC and on activated T cells. Histological analysis of serial spleen sections revealed a CD83 expression pattern resembling that of MIDC-8, a known murine DC marker molecule. In contrast to other costimulatory receptors, cross-linking of CD83 with the mAb Michel-17 on DC or T cells does not induce any activation signals. Our data describe for the first time the expression pattern of murine CD83, which is comparable to that of human CD83. The unique mAb Michel-17 will help to elucidate the biological functions of the CD83 molecule in more detail.

Entities: Gene Species

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Year: 2003 PMID： 12687354 DOI： 10.1007/s00430-003-0179-9

Source DB: PubMed Journal: Med Microbiol Immunol ISSN： 0300-8584 Impact factor: 3.402

15 in total

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