Literature DB >> 12686443

Antioxidant and free radical scavenging activity of flavonol glycosides from different Aconitum species.

Alessandra Braca1, Gelsomina Fico, Ivano Morelli, Francesco De Simone, Franca Tomè, Nunziatina De Tommasi.   

Abstract

Bioassay-guided fractionation by 1,1-diphenyl-2-dipicrylhydrazyl (DPPH) radical scavenging test of polar extracts of some Italian Aconitum species (A. napellus subsp. tauricum, A. napellus subsp. neomontanum, A. paniculatum, A. vulparia) led to the isolation of 13 flavonol glycosides: quercetin 3-O-(6-trans-caffeoyl)-beta-glucopyranosyl-(1-->2)-beta-glucopyranoside-7-O-alpha-rhamnopyranoside (1), kaempferol 3-O-(6-trans-caffeoyl)-beta-glucopyranosyl-(1-->2)-beta-glucopyranoside-7-O-alpha-rhamnopyranoside (2), quercetin 3-O-(6-trans-p-coumaroyl)-beta-glucopyranosyl-(1-->2)-beta-glucopyranoside-7-O-alpha-rhamnopyranoside (3), kaempferol 3-O-(6-trans-p-coumaroyl)-beta-glucopyranosyl-(1-->2)-beta-glucopyranoside-7-O-alpha-rhamnopyranoside (4), quercetin 7-O-(6-trans-caffeoyl)-beta-glucopyranosyl-(1-->3)-alpha-rhamnopyranoside-3-O-beta-glucopyranoside (5), kaempferol 7-O-(6-trans-caffeoyl)-beta-glucopyranosyl-(1-->3)-alpha-rhamnopyranoside-3-O-beta-glucopyranoside (6), kaempferol 7-O-(6-trans-p-coumaroyl)-beta-glucopyranosyl-(1-->3)-alpha-rhamnopyranoside-3-O-beta-glucopyranoside (7), kaempferol 3-O-beta-(2"-acetyl)galactopyranoside (8), kaempferol 3-O-beta-(2"-acetyl)galactopyranoside-7-O-alpha-arabinopyranoside (9), quercetin 3-O-beta-(2"-acetyl)galactopyranoside-7-O-alpha-arabinopyranoside (10), quercetin 3,7-di-O-alpha-rhamnopyranoside (11), kaempferol 3,7-di-O-alpha-rhamnopyranoside (12) and quercetin 3-O-beta-glucopyranoside-7-O-alpha-rhamnopyranoside (13). Their antioxidant activity (AA) was determined by measuring free radical scavenging activity by DPPH test and the coupled oxidation of beta-carotene and linoleic acid assay. The results showed that 5 is the most active compound in the DPPH free-radical scavenging test (IC(50) 1.9 microM) while in the coupled oxidation of beta-carotene and linoleic acid assay compound 1 has the highest inhibitory ratio after 1h (58.9%). Some structure-activity relationships on the AA were obtained.

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Year:  2003        PMID： 12686443     DOI： 10.1016/s0378-8741(03)00043-6

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  20 in total

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Authors:  Daniel K Owens; Anne B Alerding; Kevin C Crosby; Aloka B Bandara; James H Westwood; Brenda S J Winkel
Journal:  Plant Physiol       Date:  2008-05-08       Impact factor: 8.340

5.  Evaluation of the Acetone and Aqueous Extracts of Mature Stem Bark of Sclerocarya birrea for Antioxidant and Antimicrobial Properties.

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Review 6.  Non-alkaloidal constituents from the genus Aconitum: a review.

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7.  A RG-II type polysaccharide purified from Aconitum coreanum alleviates lipopolysaccharide-induced inflammation by inhibiting the NF-κB signal pathway.

Authors:  Xiaojun Li; Jiaye Jiang; Songshan Shi; S W Annie Bligh; Yuan Li; Yongbo Jiang; Dan Huang; Yan Ke; Shunchun Wang
Journal:  PLoS One       Date:  2014-06-13       Impact factor: 3.240

8.  Qualitative and quantitative analysis of flavonoids from 12 species of Korean mulberry leaves.

Authors:  Wan-Taek Ju; O-Chul Kwon; Hyun-Bok Kim; Gyoo-Byung Sung; Heon-Woong Kim; Yong-Soon Kim
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9.  Gastroprotective Effect of Ginger Rhizome (Zingiber officinale) Extract: Role of Gallic Acid and Cinnamic Acid in H(+), K(+)-ATPase/H. pylori Inhibition and Anti-Oxidative Mechanism.

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Journal:  Evid Based Complement Alternat Med       Date:  2011-06-23       Impact factor: 2.629

10.  Antioxidant, Hepatoprotective, and Antidepression Effects of Rumex tingitanus Extracts and Identification of a Novel Bioactive Compound.

Authors:  Dhekra Mhalla; Karama Zouari Bouassida; Rachid Chawech; Amira Bouaziz; Samar Makni; Lobna Jlaiel; Slim Tounsi; Raoudha Mezghani Jarraya; Mohamed Trigui
Journal:  Biomed Res Int       Date:  2018-03-18       Impact factor: 3.411
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