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Literature DB >> 1268613

Folate-responsive neuropathy: report of 10 cases.

Abstract

Ten patients with severe neurological disease that was clinically indistinguishable from subacute combined degeneration of the spinal cord were found to have normal serum vitamin B12 levels. All were folate deficient. Specific folate treatment led to significant reversal of the neuropathy. These findings indicate the need to review orthodox concepts of the role of folic acid in maintaining the integrity of the nervous system.

Entities: Chemical Disease Species

Mesh：

Substances：
Folic Acid
Vitamin B 12

Year: 1976 PMID： 1268613 PMCID： PMC1639752 DOI： 10.1136/bmj.1.6019.1176

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

9 in total

1. IRON DEFICIENCY AND ITS RELATION TO FOLIC-ACID STATUS IN PREGNANCY: RESULTS OF A CLINICAL TRIAL.

Authors: I CHANARIN; D ROTHMAN; V BERRY
Journal: Br Med J Date: 1965-02-20

2. RELATIVE FOLATE DEFICIENCY OF ERYTHROCYTES IN PERNICIOUS ANEMIA AND ITS CORRECTION WITH CYANOCOBALAMIN.

Authors: B A COOPER; L LOWENSTEIN
Journal: Blood Date: 1964-11 Impact factor: 22.113

3. Reversible central nervous system dysfunction in folate deficiency.

Authors: E Melamed; A Reches; C Hershko
Journal: J Neurol Sci Date: 1975-05 Impact factor: 3.181

4. Relation of abnormal folate metabolism to neuropathy developing during anticonvulsant drug therapy.

Authors: S J Horwitz; F A Klipstein; R E Lovelace
Journal: Lancet Date: 1968-03-16 Impact factor: 79.321

5. Subacute combined system degeneration with folate deficiency.

Authors: J H Pincus; E H Reynolds; G H Glaser
Journal: JAMA Date: 1972-07-31 Impact factor: 56.272

6. Congenital defects in folate utilization.

Authors: T Arakawa
Journal: Am J Med Date: 1970-05 Impact factor: 4.965

7. Nutritional studies on the entrants to an old people's home, with particular reference to folic-acid deficiency.

Authors: A E Read; K R Gough; J L Pardoe; A Nicholas
Journal: Br Med J Date: 1965-10-09

8. Lactobacillus casei C.S.F. folate activity.

Authors: D G Wells; H J Casey
Journal: Br Med J Date: 1967-09-30

9. Folate-responsive homocystinuria and "schizophrenia". A defect in methylation due to deficient 5,10-methylenetetrahydrofolate reductase activity.

Authors: J M Freeman; J D Finkelstein; S H Mudd
Journal: N Engl J Med Date: 1975-03-06 Impact factor: 91.245

9 in total

11 in total

1. Editorial: Folate deficiency and the nervous system.

Authors:
Journal: Br Med J Date: 1976-07-10

2. Effect of chronic valproate treatment on folate-dependent methyl biosynthesis in the rat.

Authors: G F Carl
Journal: Neurochem Res Date: 1986-05 Impact factor: 3.996

3. Pathology of folate deficiency.

Authors: A V Hoffbrand
Journal: Proc R Soc Med Date: 1977-02

4. Methyl group deficiency in nerve tissue: a hypothesis to explain the lesion of subacute combined degeneration.

Authors: J J Dinn; D G Weir; S McCann; B Reed; P Wilson; J M Scott
Journal: Ir J Med Sci Date: 1980-01 Impact factor: 1.568

Review 5. Drugs and folate metabolism.

Authors: D G Lambie; R H Johnson
Journal: Drugs Date: 1985-08 Impact factor: 9.546

10. Folic acid and melatonin ameliorate carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats.

Authors: Hossam Ebaid; Samir Ae Bashandy; Ibrahim M Alhazza; Ahmed Rady; Sultan El-Shehry
Journal: Nutr Metab (Lond) Date: 2013-02-03 Impact factor: 4.169