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Literature DB >> 12686122

The multi-functional topa-quinone copper amine oxidases.

Abstract

The mature copper amine oxidases (CAOs) contain a tyrosine-derived 2,4,5-trihydroxyphenylalanyl quinone (topa quinone or TPQ) and a cupric ion in close proximity. Through a combination of structural, spectroscopic and kinetic analyses, a chemical mechanism for the self-processing of an active site tyrosine to TPQ has been proposed. Once formed, TPQ acts as a switch between the heterolytic transformation of amine substrates to aldehydes, via a pyridoxal phosphate-like Schiff base complex, and one electron chemistry involving reduction of molecular oxygen. The relationship between the biogenetic and catalytic processes is discussed.

Entities: Chemical Gene

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Year: 2003 PMID： 12686122 DOI： 10.1016/s1570-9639(03)00077-3

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

25 in total

1. Identification of the disulfide bonds of lysyl oxidase.

Authors: Xi Chen; Frederick T Greenaway
Journal: J Neural Transm (Vienna) Date: 2010-12-28 Impact factor: 3.575

2. Reversible inhibition of copper amine oxidase activity by channel-blocking ruthenium(II) and rhenium(I) molecular wires.

Authors: Stephen M Contakes; Gregory A Juda; David B Langley; Nicholas W Halpern-Manners; Anthony P Duff; Alexander R Dunn; Harry B Gray; David M Dooley; J Mitchell Guss; Hans C Freeman
Journal: Proc Natl Acad Sci U S A Date: 2005-09-12 Impact factor: 11.205

Review 3. Human copper-dependent amine oxidases.

Authors: Joel Finney; Hee-Jung Moon; Trey Ronnebaum; Mason Lantz; Minae Mure
Journal: Arch Biochem Biophys Date: 2014-01-06 Impact factor: 4.013

4. Finely tuned regulation of the aromatic amine degradation pathway in Escherichia coli.

Authors: Ji Zeng; Stephen Spiro
Journal: J Bacteriol Date: 2013-09-06 Impact factor: 3.490

Review 5. Copper active sites in biology.

Authors: Edward I Solomon; David E Heppner; Esther M Johnston; Jake W Ginsbach; Jordi Cirera; Munzarin Qayyum; Matthew T Kieber-Emmons; Christian H Kjaergaard; Ryan G Hadt; Li Tian
Journal: Chem Rev Date: 2014-03-03 Impact factor: 60.622

The multi-functional topa-quinone copper amine oxidases.

1. Identification of the disulfide bonds of lysyl oxidase.

2. Reversible inhibition of copper amine oxidase activity by channel-blocking ruthenium(II) and rhenium(I) molecular wires.

Review 3. Human copper-dependent amine oxidases.

4. Finely tuned regulation of the aromatic amine degradation pathway in Escherichia coli.

Review 5. Copper active sites in biology.

Review 6. Ectoenzymes in leukocyte migration and their therapeutic potential.

7. Vascular adhesion protein-1 is involved in both acute and chronic inflammation in the mouse.

8. Structural organization of mammalian copper-containing amine oxidase genes.

9. Co(II) is not oxidized during turnover in the copper amine oxidase from Hansenula polymorpha.

10. Fluorescein-N-Methylimidazole Conjugate as Cu(2+) Sensor in Mixed Aqueous Media Through Electron Transfer.