Literature DB >> 12685603

Analysis of the active components of silymarin.

F Kvasnicka1, B Bíba, R Sevcík, M Voldrich, J Krátká.   

Abstract

Silymarin is an antihepatotoxic substance isolated from fruits of Silybum marianum. Possibly due to their antioxidant and membrane stabilizing properties, the compounds have been shown to protect different organs and cells against a number of insults. The content and composition of main silymarin components (silybin, isosilybin, silydianin and silychristin) in various pharmaceuticals were analysed using HPLC and newly developed capillary zone electrophoresis method. Antioxidant properties expressed as total antioxidant status (TAS) of silymarin components were studied. Results of TAS were correlated with electropherograms and chromatograms.

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Year:  2003        PMID： 12685603     DOI： 10.1016/s0021-9673(02)01971-4

Source DB:  PubMed          Journal:  J Chromatogr A        ISSN： 0021-9673            Impact factor:   4.759


  38 in total

Review 1.  Silybin and the liver: from basic research to clinical practice.

Authors:  Carmela Loguercio; Davide Festi
Journal:  World J Gastroenterol       Date:  2011-05-14       Impact factor: 5.742

2.  Silymarin glyceryl monooleate/poloxamer 407 liquid crystalline matrices: physical characterization and enhanced oral bioavailability.

Authors:  Ruyue Lian; Yi Lu; Jianping Qi; Yanan Tan; Mengmeng Niu; Peipei Guan; Fuqiang Hu; Wei Wu
Journal:  AAPS PharmSciTech       Date:  2011-09-23       Impact factor: 3.246

3.  Mixed micelles loaded with silybin-polyene phosphatidylcholine complex improve drug solubility.

Authors:  Rui-ling Duan; Xun Sun; Jie Liu; Tao Gong; Zhi-rong Zhang
Journal:  Acta Pharmacol Sin       Date:  2010-12-20       Impact factor: 6.150

4.  Silymarin mitigates lung impairments in a rat model of acute respiratory distress syndrome.

Authors:  Zhongming Zhu; Gengyun Sun
Journal:  Inflammopharmacology       Date:  2017-11-02       Impact factor: 4.473

Review 5.  Herb-drug interactions: a literature review.

Authors:  Zeping Hu; Xiaoxia Yang; Paul Chi Lui Ho; Sui Yung Chan; Paul Wan Sia Heng; Eli Chan; Wei Duan; Hwee Ling Koh; Shufeng Zhou
Journal:  Drugs       Date:  2005       Impact factor: 9.546

6.  Preparation, characterization and evaluation of Marsupsin-phospholipid complex.

Authors:  Mukesh S Sikarwar; Shalini Sharma; Amit K Jain; S D Parial
Journal:  AAPS PharmSciTech       Date:  2008-01-18       Impact factor: 3.246

7.  Effect of silymarin on the pharmacokinetics of losartan and its active metabolite E-3174 in healthy Chinese volunteers.

Authors:  Yang Han; Dong Guo; Yao Chen; Yu Chen; Zhi-Rong Tan; Hong-Hao Zhou
Journal:  Eur J Clin Pharmacol       Date:  2009-02-17       Impact factor: 2.953

8.  HiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin case.

Authors:  José G Napolitano; David C Lankin; Tyler N Graf; J Brent Friesen; Shao-Nong Chen; James B McAlpine; Nicholas H Oberlies; Guido F Pauli
Journal:  J Org Chem       Date:  2013-03-05       Impact factor: 4.354

9.  Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity.

Authors:  Suvadra Das; Partha Roy; Runa Ghosh Auddy; Arup Mukherjee
Journal:  Int J Nanomedicine       Date:  2011-06-22

10.  Silymarin-loaded solid nanoparticles provide excellent hepatic protection: physicochemical characterization and in vivo evaluation.

Authors:  Kwan Yeol Yang; Du Hyeong Hwang; Abid Mehmood Yousaf; Dong Wuk Kim; Young-Jun Shin; Ok-Nam Bae; Yong-Il Kim; Jong Oh Kim; Chul Soon Yong; Han-Gon Choi
Journal:  Int J Nanomedicine       Date:  2013-08-28
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