| Literature DB >> 12684912 |
Sonya Shin1, Dalia Guerra, Michael Rich, Kwonjune J Seung, Joia Mukherjee, Keith Joseph, Rocio Hurtado, Felix Alcantara, Jaime Bayona, Cesar Bonilla, Paul Farmer, Jennifer Furin.
Abstract
Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem affecting women of childbearing age. Little is known, however, about the safety of the drugs used to treat MDR-TB during pregnancy. We describe 7 patients who were treated for MDR-TB during pregnancy. These patients had chronic tuberculosis that had caused extensive parenchymal damage and had high-grade resistance to antituberculous drugs. All patients received individualized antituberculous therapy prior to delivery of healthy term infants. Neither obstetrical complications nor perinatal transmission of MDB-TB was observed. One patient experienced treatment failure, and another abandoned therapy. The other 5 patients are currently cured or in treatment and have culture-negative status. In each of these 7 cases, excellent treatment outcomes were obtained for the women and their children. Under certain circumstances, MDR-TB can be successfully treated during pregnancy.Entities:
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Year: 2003 PMID： 12684912 DOI： 10.1086/374225
Source DB: PubMed Journal: Clin Infect Dis ISSN： 1058-4838 Impact factor: 9.079