Literature DB >> 12683950

Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor.

Laurent O Mosnier1, John H Griffin.   

Abstract

In a model of staurosporine-induced apoptosis using EAhy926 endothelial cells, inhibition of apoptosis by activated protein C was dose-dependent and required the enzyme's active site, implicating activated protein C-mediated proteolysis. Consistent with this implication, both protease-activated receptor-1 (PAR-1) and endothelial cell protein C receptor (EPCR) were required for the anti-apoptotic effects of activated protein C.

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Year:  2003        PMID： 12683950      PMCID： PMC1223481          DOI： 10.1042/BJ20030341

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  26 in total

Review 1.  The endothelial cell protein C receptor.

Authors:  C T Esmon
Journal:  Thromb Haemost       Date:  2000-05       Impact factor: 5.249

2.  The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis.

Authors:  F B Taylor; D J Stearns-Kurosawa; S Kurosawa; G Ferrell; A C Chang; Z Laszik; S Kosanke; G Peer; C T Esmon
Journal:  Blood       Date:  2000-03-01       Impact factor: 22.113

3.  Plasmin desensitization of the PAR1 thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapy.

Authors:  A Kuliopulos; L Covic; S K Seeley; P J Sheridan; J Helin; C E Costello
Journal:  Biochemistry       Date:  1999-04-06       Impact factor: 3.162

Review 4.  Regulation of blood coagulation.

Authors:  C T Esmon
Journal:  Biochim Biophys Acta       Date:  2000-03-07

5.  YOPRO-1 permits cytofluorometric analysis of programmed cell death (apoptosis) without interfering with cell viability.

Authors:  T Idziorek; J Estaquier; F De Bels; J C Ameisen
Journal:  J Immunol Methods       Date:  1995-09-25       Impact factor: 2.303

6.  Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va.

Authors:  A J Gale; X Sun; M J Heeb; J H Griffin
Journal:  Protein Sci       Date:  1997-01       Impact factor: 6.725

7.  Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex.

Authors:  P Fuentes-Prior; Y Iwanaga; R Huber; R Pagila; G Rumennik; M Seto; J Morser; D R Light; W Bode
Journal:  Nature       Date:  2000-03-30       Impact factor: 49.962

8.  One single mRNA encodes the centrosomal protein CCD41 and the endothelial cell protein C receptor (EPCR).

Authors:  K Rothbarth; A R Dabaghian; H Stammer; D Werner
Journal:  FEBS Lett       Date:  1999-09-10       Impact factor: 4.124

9.  The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

Authors:  D J Stearns-Kurosawa; S Kurosawa; J S Mollica; G L Ferrell; C T Esmon
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

10.  Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR.

Authors:  K Fukudome; C T Esmon
Journal:  J Biol Chem       Date:  1995-03-10       Impact factor: 5.157
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  81 in total

1.  Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier Stabilization.

Authors:  Ranjeet K Sinha; Xia V Yang; José A Fernández; Xiao Xu; Laurent O Mosnier; John H Griffin
Journal:  Arterioscler Thromb Vasc Biol       Date:  2016-01-21       Impact factor: 8.311

2.  Tick saliva is a potent inhibitor of endothelial cell proliferation and angiogenesis.

Authors:  Ivo M B Francischetti; Thomas N Mather; José M C Ribeiro
Journal:  Thromb Haemost       Date:  2005-07       Impact factor: 5.249

3.  Global analysis of endothelial cell line proliferation patterns based on nutrient-depletion models: implications for a standardization of cell proliferation assays.

Authors:  P Tracqui; J W Liu; O Collin; J Clement-Lacroix; E Planus
Journal:  Cell Prolif       Date:  2005-06       Impact factor: 6.831

4.  Activated protein C promotes breast cancer cell migration through interactions with EPCR and PAR-1.

Authors:  Lea M Beaulieu; Frank C Church
Journal:  Exp Cell Res       Date:  2006-12-14       Impact factor: 3.905

5.  Roles of protease-activated receptors in a mouse model of endotoxemia.

Authors:  Eric Camerer; Ivo Cornelissen; Hiroshi Kataoka; Daniel N Duong; Yao-Wu Zheng; Shaun R Coughlin
Journal:  Blood       Date:  2006-01-24       Impact factor: 22.113

Review 6.  Sepsis: a clinical update.

Authors:  Corey E Ventetuolo; Mitchell M Levy
Journal:  Clin J Am Soc Nephrol       Date:  2007-11-07       Impact factor: 8.237

7.  Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity.

Authors:  Yaoming Wang; Meenakshisundaram Thiyagarajan; Nienwen Chow; Itender Singh; Huang Guo; Thomas P Davis; Berislav V Zlokovic
Journal:  Stroke       Date:  2008-12-04       Impact factor: 7.914

Review 8.  2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C.

Authors:  John H Griffin; Laurent O Mosnier; José A Fernández; Berislav V Zlokovic
Journal:  Arterioscler Thromb Vasc Biol       Date:  2016-10-06       Impact factor: 8.311

9.  The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells.

Authors:  Jong-Sup Bae; Likui Yang; Chandrashekhara Manithody; Alireza R Rezaie
Journal:  Blood       Date:  2007-09-06       Impact factor: 22.113

10.  Endothelial cell protein C receptor opposes mesothelioma growth driven by tissue factor.

Authors:  Shiva Keshava; Sanghamitra Sahoo; Torry A Tucker; Steven Idell; L Vijaya Mohan Rao; Usha R Pendurthi
Journal:  Cancer Res       Date:  2013-03-28       Impact factor: 12.701
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