Literature DB >> 12683802

Directed denaturation: room temperature and stoichiometric unfolding of cytochrome C by a metalloporphyrin dimer.

Andrew J Wilson1, Kevin Groves, Rishi K Jain, Hyung Soon Park, Andrew D Hamilton.   

Abstract

Using circular dichroism, UV-vis, and trypsin proteolysis, we have shown how a metalloporphyrin dimer induces the unfolding of a protein, cytochrome c, under physiologically relevant conditions and accelerates its rate of proteolytic degradation.

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Year:  2003        PMID： 12683802     DOI： 10.1021/ja028574m

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  7 in total

Review 1.  Targeting protein-protein interactions by rational design: mimicry of protein surfaces.

Authors:  Steven Fletcher; Andrew D Hamilton
Journal:  J R Soc Interface       Date:  2006-04-22       Impact factor: 4.118

2.  Selective protein-surface sensing using ruthenium(II) tris(bipyridine) complexes.

Authors:  James Muldoon; Alison E Ashcroft; Andrew J Wilson
Journal:  Chemistry       Date:  2010-01-04       Impact factor: 5.236

3.  Surface binding inhibitors of the SCF-KIT protein-protein interaction.

Authors:  David Margulies; Yarden Opatowsky; Steven Fletcher; Ishu Saraogi; Lun K Tsou; Sourav Saha; Irit Lax; Joseph Schlessinger; Andrew D Hamilton
Journal:  Chembiochem       Date:  2009-08-17       Impact factor: 3.164

4.  A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression.

Authors:  Zoë A E Waller; Sven A Sewitz; Shang-Te Danny Hsu; Shankar Balasubramanian
Journal:  J Am Chem Soc       Date:  2009-09-09       Impact factor: 15.419

5.  Protein destabilisation by ruthenium(II) tris-bipyridine based protein-surface mimetics.

Authors:  Andrew J Wilson; James R Ault; Maria H Filby; Hazel I A Philips; Alison E Ashcroft; Nicholas C Fletcher
Journal:  Org Biomol Chem       Date:  2013-04-07       Impact factor: 3.876

6.  Protein surface recognition using geometrically pure Ru(II) tris(bipyridine) derivatives.

Authors:  Maria H Filby; James Muldoon; Serin Dabb; Nicholas C Fletcher; Alison E Ashcroft; Andrew J Wilson
Journal:  Chem Commun (Camb)       Date:  2010-11-23       Impact factor: 6.222

Review 7.  NMR Spectroscopy of supramolecular chemistry on protein surfaces.

Authors:  Peter Bayer; Anja Matena; Christine Beuck
Journal:  Beilstein J Org Chem       Date:  2020-10-09       Impact factor: 2.883
  7 in total

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