Literature DB >> 12683554

Is the female gender an independent predictor of adverse outcome after off-pump coronary artery bypass grafting?

Thanos Athanasiou1, Sharif Al-Ruzzeh, Rex Del Stanbridge, Roberto P Casula, Brian E Glenville, Mohamed Amrani.   

Abstract

BACKGROUND: The female gender is an independent predictor of adverse outcome after conventional coronary artery bypass grafting using cardiopulmonary bypass. The aim of this study is to assess the effect of the female gender on the outcome after off-pump coronary artery bypass (OPCAB) surgery.
METHODS: This study is a retrospective review of 413 consecutive patients (181 women and 232 men) who underwent OPCAB between January 1999 and May 2001. Adverse outcomes were divided into minor adverse outcomes (MINAO), major adverse outcomes (MAJAO), and prolonged length of stay (PLOS) more than 7 days. MINAO included atrial fibrillation, respiratory complications except adult respiratory distress syndrome, and any wound infection except mediastinitis. MAJAO included stroke, myocardial infarction, renal failure, adult respiratory distress syndrome, mediastinitis, low cardiac output, mechanical ventilation more than 24 hours, intensive therapy unit stay more than 24 hours, gastrointestinal complications, cardiorespiratory arrest, and mortality within 30 days. Preoperative and intraoperative variables were evaluated as predictors of MINAO, MAJAO, and PLOS by univariate and multivariate analyses.
RESULTS: The groups were matched for age and Parsonnet score-predicted mortality. However, the women had a higher incidence of chronic obstructive airway disease (p = 0.04), diabetes (p = 0.01), obesity (p = 0.000), peripheral vascular disease (p = 0.000), hypertension (p = 0.000), unstable angina (p = 0.005), history of previous failed nonsurgical intervention (p = 0.02), and nonelective operation (p = 0.000). There were a fewer number of grafts performed in the female group (2.8 vs 3.4, p = 0.000), with the circumflex territory being revascularised less frequently (p = 0.001). Univariate analysis identified the female gender to be a predictor of only MINAO (p = 0.001) and PLOS (p = 0.000). However, with multivariate analysis, female gender was not found to be an independent predictor of MINAO, MAJAO, or PLOS.
CONCLUSIONS: In OPCAB, the female gender is not an independent predictor of MINAO, MAJAO, or PLOS.

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Year:  2003        PMID: 12683554     DOI: 10.1016/s0003-4975(02)04757-4

Source DB:  PubMed          Journal:  Ann Thorac Surg        ISSN: 0003-4975            Impact factor:   4.330


  5 in total

1.  The real-world outcomes of off-pump coronary artery bypass surgery in a public health care system.

Authors:  Veena Guru; Kevin W Glasgow; Stephen E Fremes; Peter C Austin; Kevin Teoh; Jack V Tu
Journal:  Can J Cardiol       Date:  2007-03-15       Impact factor: 5.223

Review 2.  A comprehensive view of sex-specific issues related to cardiovascular disease.

Authors:  Louise Pilote; Kaberi Dasgupta; Veena Guru; Karin H Humphries; Jennifer McGrath; Colleen Norris; Doreen Rabi; Johanne Tremblay; Arsham Alamian; Tracie Barnett; Jafna Cox; William Amin Ghali; Sherry Grace; Pavel Hamet; Teresa Ho; Susan Kirkland; Marie Lambert; Danielle Libersan; Jennifer O'Loughlin; Gilles Paradis; Milan Petrovich; Vicky Tagalakis
Journal:  CMAJ       Date:  2007-03-13       Impact factor: 8.262

Review 3.  Pulmonary pathophysiology and lung mechanics in anesthesiology: a case-based overview.

Authors:  Marcos F Vidal Melo; Guido Musch; David W Kaczka
Journal:  Anesthesiol Clin       Date:  2012-09-01

4.  Early and mid term mortality after coronary artery bypass grafting in women depends on the surgical protocol: retrospective analysis of 3441 on- and off-pump coronary artery bypass grafting procedures.

Authors:  Sandra Eifert; Eckehard Kilian; Andres Beiras-Fernandez; Gerd Juchem; Bruno Reichart; Peter Lamm
Journal:  J Cardiothorac Surg       Date:  2010-10-25       Impact factor: 1.637

5.  Female Gender is not a Risk Factor for Early Mortality after Coronary Artery Bypass Grafting.

Authors:  Akhil Gurram; Neethu Krishna; Anu Vasudevan; Luis Alberto Baquero; Aveek Jayant; Praveen Kerala Varma
Journal:  Ann Card Anaesth       Date:  2019 Apr-Jun
  5 in total

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