Literature DB >> 12682734

[The treatment of necrotizing otitis externa with a combination of surgery, antibiotics, specific immunoglobulins and hyperbaric oxygen therapy. Results of the Ulm Treatment Concept].

M Tisch1, K J Lorenz, M Harm, L Lampl, H Maier.   

Abstract

BACKGROUND: Even today, necrotizing otitis externa is still a life-threatening condition. The standard treatment concepts based on antibiotic therapy, topical treatment and--if necessary--surgical debridement of necrotic tissue, remain ineffective in many cases. In advanced stages, necrotizing otitis externa can therefore be expected to result in severe functional impairment or even a fatal outcome. PATIENTS AND METHODS: We describe our experience with a multimodal treatment concept that we have been using with great success at the Federal Armed Forces Hospital in Ulm since 1987. This treatment is based on four pillars: 1. Surgical debridement, 2. Use of a combination of antibiotics, and 3. Administration of specific immunoglobulins, accompanied by, 4. Hyperbaric oxygen therapy
RESULTS: Over a period of more than 5 years 16 of the 22 patients treated on the basis of this multimodal concept remained free of recurrences. In addition, significant reductions in analgesic use and in the insulin doses needed by diabetic patients were possible.
CONCLUSIONS: The treatment concept under scrutiny has proved particularly successful. The various modes involved and the results of this combined therapy are discussed.

Entities:  

Mesh:

Substances:

Year:  2003        PMID: 12682734     DOI: 10.1007/s00106-002-0713-x

Source DB:  PubMed          Journal:  HNO        ISSN: 0017-6192            Impact factor:   1.284


  5 in total

1.  Value of hyperbaric oxygen in bacterial and fungal malignant external otitis treatment.

Authors:  Waldemar Narozny; Jerzy Kuczkowski; Czeslaw Stankiewicz; Jacek Kot; Boguslaw Mikaszewski; Tomasz Przewozny
Journal:  Eur Arch Otorhinolaryngol       Date:  2006-04-22       Impact factor: 2.503

2.  [Topical immunomodulation in the treatment of therapy resistant, non-infectious otitis externa].

Authors:  M Tisch
Journal:  HNO       Date:  2008-06       Impact factor: 1.284

3.  Central skull base osteomyelitis: new insights and implications for diagnosis and treatment.

Authors:  Gerd J Ridder; Christine Breunig; Jan Kaminsky; Jens Pfeiffer
Journal:  Eur Arch Otorhinolaryngol       Date:  2014-11-09       Impact factor: 2.503

Review 4.  Otitis Externa.

Authors:  Susanne Wiegand; Reinhard Berner; Antonius Schneider; Ellen Lundershausen; Andreas Dietz
Journal:  Dtsch Arztebl Int       Date:  2019-03-29       Impact factor: 5.594

5.  [Topical immunomodulation. A milestone for the treatment of therapy-resistant noninfectious chronic external otitis?].

Authors:  P P Caffier; W Harth; B Mayelzadeh; H Haupt; H Scherer; B Sedlmaier
Journal:  HNO       Date:  2008-05       Impact factor: 1.284

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.