OBJECTIVE: To determine the validity of predictive equations in calculating oxygen consumption (Vo(2)) in ventilated patients with congenital heart disease. DESIGN: Prospective study. SETTING: Cardiac catheterization laboratories and intensive care units of two university teaching hospitals. PATIENTS: A total of 126 patients with congenital heart disease were studied. Of these, 75 patients received anesthesia in the pediatric cardiac catheterization laboratory, and 51 were deeply sedated in the intensive care unit after open heart surgery. MEASUREMENTS AND MAIN RESULTS: Vo(2) was measured directly in all patients using respiratory mass spectrometry. Estimated values for absolute Vo(2) (mL/min) and indexed Vo(2) (mL.min-1.m-2) were calculated from the four predictive equations published by LaFarge and Miettinen, Lundell et al., Wessel et al., and Lindahl. The agreement between measured and estimated Vo(2) was evaluated by calculating their bias and limits of agreement. A failure of agreement between measured and estimated Vo(2) was noted in both groups of patients, irrespective the equation used, and the agreement was poorer in patients in the intensive care unit. The equation by LaFarge and Miettinen produced the closest estimation in patients at cardiac catheterization with a bias of 4.5 mL/min for absolute Vo(2) and 6.9 mL.min-1.m-2 for indexed Vo(2). A systematic error of overestimating lower and underestimating higher indexed Vo(2) mL.min-1.m-2 was introduced in both groups. CONCLUSION: Predictive equations do not accurately estimate Vo(2) in ventilated patients with congenital heart disease.
OBJECTIVE: To determine the validity of predictive equations in calculating oxygen consumption (Vo(2)) in ventilated patients with congenital heart disease. DESIGN: Prospective study. SETTING: Cardiac catheterization laboratories and intensive care units of two university teaching hospitals. PATIENTS: A total of 126 patients with congenital heart disease were studied. Of these, 75 patients received anesthesia in the pediatric cardiac catheterization laboratory, and 51 were deeply sedated in the intensive care unit after open heart surgery. MEASUREMENTS AND MAIN RESULTS:Vo(2) was measured directly in all patients using respiratory mass spectrometry. Estimated values for absolute Vo(2) (mL/min) and indexed Vo(2) (mL.min-1.m-2) were calculated from the four predictive equations published by LaFarge and Miettinen, Lundell et al., Wessel et al., and Lindahl. The agreement between measured and estimated Vo(2) was evaluated by calculating their bias and limits of agreement. A failure of agreement between measured and estimated Vo(2) was noted in both groups of patients, irrespective the equation used, and the agreement was poorer in patients in the intensive care unit. The equation by LaFarge and Miettinen produced the closest estimation in patients at cardiac catheterization with a bias of 4.5 mL/min for absolute Vo(2) and 6.9 mL.min-1.m-2 for indexed Vo(2). A systematic error of overestimating lower and underestimating higher indexed Vo(2) mL.min-1.m-2 was introduced in both groups. CONCLUSION: Predictive equations do not accurately estimate Vo(2) in ventilated patients with congenital heart disease.
Authors: Alejandro A Floh; Gustavo La Rotta; Julius Z Wermelt; Patricia Bastero-Miñón; V Ben Sivarajan; Tilman Humpl Journal: Intensive Care Med Date: 2013-02-22 Impact factor: 17.440
Authors: Long Guo; Yong Cui; Scott Pharis; Mark Walsh; Joseph Atallah; Meng-Wei Tan; Jennifer Rutledge; J Y Coe; Ian Adatia Journal: Pediatr Cardiol Date: 2013-12-19 Impact factor: 1.655
Authors: Zaher Fanari; Anitha Rajamanickam; Mathew Grove; Sumaya Hammami; Cassie Walls; Paul Kolm; William Weintraub; Andrew J Doorey Journal: Del Med J Date: 2016-07
Authors: Zaher Fanari; Matthew Grove; Anitha Rajamanickam; Sumaya Hammami; Cassie Walls; Paul Kolm; Mitchell Saltzberg; William S Weintraub; Andrew J Doorey Journal: Del Med J Date: 2016-09
Authors: Michal Schäfer; Uyen Truong; Lorna P Browne; Gareth J Morgan; Michael Ross; Richard Ing; Kendall S Hunter; Vitaly O Kheyfets; Steven H Abman; D Dunbar Ivy; Neil Wilson Journal: Pediatr Cardiol Date: 2017-10-17 Impact factor: 1.655
Authors: Zaher Fanari; Matthew Grove; Anitha Rajamanickam; Sumaya Hammami; Cassie Walls; Paul Kolm; Mitchell Saltzberg; William S Weintraub; Andrew J Doorey Journal: Cardiovasc Revasc Med Date: 2016-02-27
Authors: Zhi Zhou; Sunil P Malhotra; Xiaoyang Yu; Jennifer Rutledge; Ivan M Rebeyka; David B Ross; Christopher Rausch; Hong Gu; Brian McCrindle; Francois Lacour-Gayet; Dunbar Ivy; Jia Li Journal: J Thorac Cardiovasc Surg Date: 2013-01-23 Impact factor: 5.209
Authors: Maria Jesus Del Cerro; Shahin Moledina; Sheila G Haworth; Dunbar Ivy; Maha Al Dabbagh; Hanaa Banjar; Gabriel Diaz; Alexandria Heath-Freudenthal; Ahmed Nasser Galal; Tilman Humpl; Snehal Kulkarni; Antonio Lopes; Ana Olga Mocumbi; G D Puri; Beyra Rossouw; S Harikrishnan; Anita Saxena; Patience Udo; Lina Caicedo; Omar Tamimi; Ian Adatia Journal: Pulm Circ Date: 2016-03 Impact factor: 3.017
Authors: Jennifer Rutledge; Andrew Bush; Lara Shekerdemian; Ingram Schulze-Neick; Daniel Penny; Sally Cai; Jia Li Journal: Am Heart J Date: 2010-07 Impact factor: 4.749