BACKGROUND: Genetic polymorphisms at codons 16 and 27 of the beta2-adrenergic receptor have been associated with altered response to sympathetic stimulation. We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study. METHODS AND RESULTS: A total of 808 black and 4441 white participants (mean age, 73 years) were genotyped for the Arg16Gly and Gln27Glu polymorphisms of the beta2-adrenergic receptor. There were 702 incident coronary events, 438 ischemic strokes, and 1136 combined cardiovascular events during 7 to 10 years of follow-up. Allele frequencies differed by race but not by age or hypertension status. Glu27 carriers had a lower risk of coronary events than Gln27 homozygotes (hazard ratio, 0.82; 95% CI, 0.70 to 0.95), and there was a suggestion of decreased risk among Gly16 carriers compared with Arg16 homozygotes (hazard ratio, 0.88; 95% CI, 0.72 to 1.07). There was no association of beta2-adrenergic receptor genotype with ischemic stroke or combined cardiovascular events. CONCLUSIONS: The Glu27 allele of the beta2-adrenergic receptor was associated with a lower risk of incident coronary events in this elderly population.
BACKGROUND: Genetic polymorphisms at codons 16 and 27 of the beta2-adrenergic receptor have been associated with altered response to sympathetic stimulation. We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study. METHODS AND RESULTS: A total of 808 black and 4441 white participants (mean age, 73 years) were genotyped for the Arg16Gly and Gln27Glu polymorphisms of the beta2-adrenergic receptor. There were 702 incident coronary events, 438 ischemic strokes, and 1136 combined cardiovascular events during 7 to 10 years of follow-up. Allele frequencies differed by race but not by age or hypertension status. Glu27 carriers had a lower risk of coronary events than Gln27 homozygotes (hazard ratio, 0.82; 95% CI, 0.70 to 0.95), and there was a suggestion of decreased risk among Gly16 carriers compared with Arg16 homozygotes (hazard ratio, 0.88; 95% CI, 0.72 to 1.07). There was no association of beta2-adrenergic receptor genotype with ischemic stroke or combined cardiovascular events. CONCLUSIONS: The Glu27 allele of the beta2-adrenergic receptor was associated with a lower risk of incident coronary events in this elderly population.
Authors: Jonathan G Zaroff; Ludmila Pawlikowska; Jacob C Miss; Sirisha Yarlagadda; Connie Ha; Achal Achrol; Pui-Yan Kwok; Charles E McCulloch; Michael T Lawton; Nerissa Ko; Wade Smith; William L Young Journal: Stroke Date: 2006-05-25 Impact factor: 7.914
Authors: Krystian Jazdzewski; Tomasz Bednarczuk; Magdalena Stepnowska; Sandya Liyanarachchi; Krystyna Suchecka-Rachon; Janusz Limon; Krzysztof Narkiewicz Journal: Int J Mol Med Date: 2007-01 Impact factor: 4.101
Authors: Alexander M Kulminski; Irina Culminskaya; Svetlana V Ukraintseva; Konstantin G Arbeev; Kenneth C Land; Anatoli I Yashin Journal: Mech Ageing Dev Date: 2010-04-24 Impact factor: 5.432
Authors: Stephen J Mooney; Stephanie T Grady; Nona Sotoodehnia; Rozenn N Lemaitre; Erin R Wallace; April F Mohanty; Jean Yee; David S Siscovick; Thomas D Rea; Barbara McKnight; Pui-Yan Kwok; Angel C Y Mak; Stephanie Hesselson; Gina S Lovasi Journal: Epidemiology Date: 2016-09 Impact factor: 4.822
Authors: C Sun; J J Wang; F M Islam; S R Heckbert; R Klein; D S Siscovick; B E K Klein; T Y Wong Journal: J Hum Hypertens Date: 2009-01-15 Impact factor: 3.012
Authors: Alfredo José Mansur; Rosana Seleri Fontes; Regina Airoldi Canzi; Raphael Nishimura; Airlane Pereira Alencar; Antonio Carlos Pedroso de Lima; José Eduardo Krieger; Alexandre Costa Pereira Journal: BMC Cardiovasc Disord Date: 2009-11-03 Impact factor: 2.298