BACKGROUND: The GRIN1 gene plays a fundamental role in many brain functions, and its involvement in the pathogenesis of the schizophrenia has been widely investigated. Non-synonymous polymorphisms have not been identified in the coding regions. To investigate the potential role of GRIN1 in the susceptibility to schizophrenia, we analyzed the G1001C polymorphism located in the promoter region in a case-control association study. METHODS: The G1001C polymorphism allele distribution was analyzed in a sample of 139 Italian schizophrenic patients and 145 healthy control subjects by a polymerase chain reaction amplification followed by digestion with a restriction endonuclease. RESULTS: We found that the C allele may alter a consensus sequence for the transcription factor NF-kappa B and that its frequency was higher in patients than in control subjects (p =.0085). The genotype distribution also was different, with p =.034 (if C allele dominant, p =.0137, odds ratio 2.037, 95% confidence interval 1.1502-3.6076). CONCLUSIONS: The association reported in this study suggests that the GRIN1 gene is a good candidate for the susceptibility to schizophrenia.
BACKGROUND: The GRIN1 gene plays a fundamental role in many brain functions, and its involvement in the pathogenesis of the schizophrenia has been widely investigated. Non-synonymous polymorphisms have not been identified in the coding regions. To investigate the potential role of GRIN1 in the susceptibility to schizophrenia, we analyzed the G1001C polymorphism located in the promoter region in a case-control association study. METHODS: The G1001C polymorphism allele distribution was analyzed in a sample of 139 Italian schizophrenicpatients and 145 healthy control subjects by a polymerase chain reaction amplification followed by digestion with a restriction endonuclease. RESULTS: We found that the C allele may alter a consensus sequence for the transcription factor NF-kappa B and that its frequency was higher in patients than in control subjects (p =.0085). The genotype distribution also was different, with p =.034 (if C allele dominant, p =.0137, odds ratio 2.037, 95% confidence interval 1.1502-3.6076). CONCLUSIONS: The association reported in this study suggests that the GRIN1 gene is a good candidate for the susceptibility to schizophrenia.
Authors: Kinsley K Kiningham; Zina-Ann Cardozo; Carla Cook; Marsha P Cole; John C Stewart; Mariela Tassone; Mitchell C Coleman; Douglas R Spitz Journal: Free Radic Biol Med Date: 2008-01-30 Impact factor: 7.376
Authors: M J Gandal; J Sisti; K Klook; P I Ortinski; V Leitman; Y Liang; T Thieu; R Anderson; R C Pierce; G Jonak; R E Gur; G Carlson; S J Siegel Journal: Transl Psychiatry Date: 2012-07-17 Impact factor: 6.222
Authors: David J Shim; Li Yang; J Graham Reed; Jeffrey L Noebels; Paul J Chiao; Hui Zheng Journal: Mol Neurodegener Date: 2011-06-10 Impact factor: 14.195