Literature DB >> 12679160

Expression of multidrug resistance protein 4 and 5 in the porcine coronary and pulmonary arteries.

Akiko Mitani1, Tsutomu Nakahara, Kenji Sakamoto, Kunio Ishii.   

Abstract

Guanosine 3',5'-cyclic monophosphate (cGMP) has an important role in regulating vascular smooth muscle tone. We examined whether mRNA for multidrug resistance protein (MRP) 4 and MRP5, which were recently identified as ATP-dependent export pumps for cyclic nucleotides, is expressed in the porcine coronary and pulmonary arteries. The results showed that both arteries express mRNA for MRP4 and MRP5, and thus these proteins may be novel targets for the prevention and/or treatment of various cardiovascular diseases.

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Year:  2003        PMID： 12679160     DOI： 10.1016/s0014-2999(03)01552-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  4 in total

1.  Nonsteroidal antiinflammatory drugs inhibiting prostanoid efflux: as easy as ABC?

Authors:  Timothy D Warner; Jane A Mitchell
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-28       Impact factor: 11.205

2.  Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart.

Authors:  Peter Dazert; Konrad Meissner; Silke Vogelgesang; Björn Heydrich; Lothar Eckel; Michael Böhm; Rolf Warzok; Reinhold Kerb; Ulrich Brinkmann; Elke Schaeffeler; Matthias Schwab; Ingolf Cascorbi; Gabriele Jedlitschky; Heyo K Kroemer
Journal:  Am J Pathol       Date:  2003-10       Impact factor: 4.307

3.  Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation.

Authors:  Yassine Sassi; Larissa Lipskaia; Grégoire Vandecasteele; Viacheslav O Nikolaev; Stéphane N Hatem; Fleur Cohen Aubart; Frans G Russel; Nathalie Mougenot; Cédric Vrignaud; Philippe Lechat; Anne-Marie Lompré; Jean-Sébastien Hulot
Journal:  J Clin Invest       Date:  2008-08       Impact factor: 14.808

4.  Effect of hypouricaemic and hyperuricaemic drugs on the renal urate efflux transporter, multidrug resistance protein 4.

Authors:  A A K El-Sheikh; J J M W van den Heuvel; J B Koenderink; F G M Russel
Journal:  Br J Pharmacol       Date:  2008-08-25       Impact factor: 8.739
  4 in total

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