| Literature DB >> 12679033 |
Yizeng Tu1, Shan Wu, Xiaohua Shi, Ka Chen, Chuanyue Wu.
Abstract
Cell-extracellular matrix adhesion is an important determinant of cell morphology. We show here that migfilin, a LIM-containing protein, localizes to cell-matrix adhesions, associates with actin filaments, and is essential for cell shape modulation. Migfilin interacts with the cell-matrix adhesion protein Mig-2 (mitogen inducible gene-2), a mammalian homolog of UNC-112, and the actin binding protein filamin through its C- and N-terminal domains, respectively. Loss of Mig-2 or migfilin impairs cell shape modulation. Mig-2 recruits migfilin to cell-matrix adhesions, while the interaction with filamin mediates the association of migfilin with actin filaments. Migfilin therefore functions as an important scaffold at cell-matrix adhesions. Together, Mig-2, migfilin and filamin define a connection between cell matrix adhesions and the actin cytoskeleton and participate in the orchestration of actin assembly and cell shape modulation.Entities:
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Year: 2003 PMID： 12679033 DOI： 10.1016/s0092-8674(03)00163-6
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582