Literature DB >> 12678676

Emerging understanding of the advantage of small molecules such as hydroxypyridinones in the treatment of iron overload.

Robert C Hider1, Zu D Liu.   

Abstract

Deferiprone, a hydroxypyridin-4-one, is effective at facilitating iron removal from iron overloaded patients, when administered orally. Some problems associated with deferiprone are discussed. Hydroxypyridinone analogues with improved distribution, metabolism and affinity for iron are described. In particular the "high pFe(3+)" hydroxypyridin-4-ones possess considerable clinical potential.

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Year:  2003        PMID： 12678676     DOI： 10.2174/0929867033457629

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  12 in total

1.  New Synthetic Approach for the Incorporation of 3,2-Hydroxypyridinone (HOPO) Ligands: Synthesis of Structurally Diverse Poly HOPO Chelators.

Authors:  Jayanthi Arumugam; Hayley A Brown; Hollie K Jacobs; Aravamudan S Gopalan
Journal:  Synthesis (Stuttg)       Date:  2011-01-01       Impact factor: 3.157

2.  Bifunctional 3-hydroxy-4-pyridinone derivatives as potential pharmaceuticals: synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation with 67Ga.

Authors:  M Amélia Santos; Marco Gil; Lurdes Gano; Sílvia Chaves
Journal:  J Biol Inorg Chem       Date:  2005-09-23       Impact factor: 3.358

3.  New methodology for the preparation of 3-hydroxy-2-pyridinone (3,2-HOPO) chelators and extractants. Part 2. Reactions of alcohols, phenols, and thiols with an electrophilic 3,2-HOPO reagent().

Authors:  Sumathi Chittamuru; Timothy N Lambert; Gloria Martinez; Hollie K Jacobs; Aravamudan S Gopalan
Journal:  Tetrahedron Lett       Date:  2007-01-20       Impact factor: 2.415

4.  Novel diaroylhydrazine ligands as iron chelators: coordination chemistry and biological activity.

Authors:  Paul V Bernhardt; Piao Chin; Philip C Sharpe; Jing-Yan C Wang; Des R Richardson
Journal:  J Biol Inorg Chem       Date:  2005-11-08       Impact factor: 3.358

5.  3,2-Hydroxypyridinone (3,2-HOPO) vinyl sulfonamide and acrylamide linkers: Aza-Michael addition reactions and the preparation of poly-HOPO chelators.

Authors:  Gloria Martinez; Jayanthi Arumugam; Hollie K Jacobs; Aravamudan S Gopalan
Journal:  Tetrahedron Lett       Date:  2013-02-13       Impact factor: 2.415

6.  Recent advances in β-thalassemias.

Authors:  Antonio Cao; Paolo Moi; Renzo Galanello
Journal:  Pediatr Rep       Date:  2011-06-16

7.  Synthesis and biological evaluation of bidentate 3-hydroxypyridin-4-ones iron chelating agents.

Authors:  L Saghaie; H Sadeghi-Aliabadi; M Kafiri
Journal:  Res Pharm Sci       Date:  2011-07

Review 8.  Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion-dependent beta thalassaemia.

Authors:  Alina Sadaf; Babar Hasan; Jai K Das; Steven Colan; Najveen Alvi
Journal:  Cochrane Database Syst Rev       Date:  2018-07-12

9.  Deferiprone in the treatment of transfusion-dependent thalassemia: a review and perspective.

Authors:  Renzo Galanello
Journal:  Ther Clin Risk Manag       Date:  2007-10       Impact factor: 2.423

10.  Stepwise design, synthesis, and in vitro antifungal screening of (Z)-substituted-propenoic acid derivatives with potent broad-spectrum antifungal activity.

Authors:  Mohammed A Khedr
Journal:  Drug Des Devel Ther       Date:  2015-08-10       Impact factor: 4.162
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