| Literature DB >> 12676587 |
David Mu1, Liyun Chen, Xiping Zhang, Lei-Hoon See, Christina M Koch, Clifford Yen, James Jiayuan Tong, Lori Spiegel, Ken C Q Nguyen, Allyson Servoss, Yue Peng, Lin Pei, Jeffrey R Marks, Scott Lowe, Timothy Hoey, Lily Yeh Jan, W Richard McCombie, Michael H Wigler, Scott Powers.
Abstract
Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal region 8q24.3. We examined a series of breast cancer samples harboring amplification of this region and determined that KCNK9 is the sole overexpressed gene within the amplification epicenter. KCNK9 encodes a potassium channel that is amplified from 3-fold to 10-fold in 10% of breast tumors and overexpressed from 5-fold to over 100-fold in 44% of breast tumors. Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation, suggesting that its amplification and overexpression plays a physiologically important role in human breast cancer.Entities:
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Year: 2003 PMID： 12676587 DOI： 10.1016/s1535-6108(03)00054-0
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743