Literature DB >> 12676580

Heat shock protein 90 as a molecular target for cancer therapeutics.

Jennifer S Isaacs1, Wanping Xu, Len Neckers.   

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Year:  2003        PMID： 12676580     DOI： 10.1016/s1535-6108(03)00029-1

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


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  190 in total

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3.  The synthetic heat shock protein 90 (Hsp90) inhibitor EC141 induces degradation of Bcr-Abl p190 protein and apoptosis of Ph-positive acute lymphoblastic leukemia cells.

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Journal:  Invest New Drugs       Date:  2010-06-09       Impact factor: 3.850

4.  17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species.

Authors:  Teneille Walker; Clint Mitchell; Margaret A Park; Adly Yacoub; Mohamed Rahmani; Dieter Häussinger; Roland Reinehr; Christina Voelkel-Johnson; Paul B Fisher; Steven Grant; Paul Dent
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5.  Global targeting of subcellular heat shock protein-90 networks for therapy of glioblastoma.

Authors:  Markus D Siegelin; Janet Plescia; Christopher M Raskett; Candace A Gilbert; Alonzo H Ross; Dario C Altieri
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6.  Development of a Grp94 inhibitor.

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7.  The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha.

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Journal:  J Immunol       Date:  2009-03-01       Impact factor: 5.422

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9.  Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships.

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10.  PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.

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