Literature DB >> 12676578

Notch and cancer: best to avoid the ups and downs.

Ivan Maillard1, Warren S Pear.   

Abstract

The Notch pathway is known for its multiple important roles in development and tissue homeostasis, and it can be subverted during oncogenic transformation. Two recent studies add to our understanding of Notch in cancer biology in contrasting ways, by showing novel mechanisms of Notch pathway activation in cancer cells, and by indicating that in some circumstances, Notch can behave as a tumor suppressor.

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Year:  2003        PMID： 12676578     DOI： 10.1016/s1535-6108(03)00052-7

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  57 in total

1.  Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA.

Authors:  Rhett A Kovall; Wayne A Hendrickson
Journal:  EMBO J       Date:  2004-08-05       Impact factor: 11.598

2.  Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method.

Authors:  Scott N Pinchot; Renata Jaskula-Sztul; Li Ning; Noel R Peters; Mackenzie R Cook; Muthusamy Kunnimalaiyaan; Herbert Chen
Journal:  Cancer       Date:  2010-11-08       Impact factor: 6.860

3.  Canonical notch signaling functions as a commitment switch in the epidermal lineage.

Authors:  Cédric Blanpain; William E Lowry; H Amalia Pasolli; Elaine Fuchs
Journal:  Genes Dev       Date:  2006-11-01       Impact factor: 11.361

4.  The gang of four gene regulates growth and patterning of the developing Drosophila eye.

Authors:  Carolyn K Beam; Kenneth Moberg
Journal:  Fly (Austin)       Date:  2010-04-24       Impact factor: 2.160

5.  NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL.

Authors:  Maria Luisa Sulis; Odette Williams; Teresa Palomero; Valeria Tosello; Sasikala Pallikuppam; Pedro J Real; Kelly Barnes; Linda Zuurbier; Jules P Meijerink; Adolfo A Ferrando
Journal:  Blood       Date:  2008-04-14       Impact factor: 22.113

6.  Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice.

Authors:  Pallavi Garg; Sabrina Jeppsson; Guillaume Dalmasso; Amr M Ghaleb; Beth B McConnell; Vincent W Yang; Andrew T Gewirtz; Didier Merlin; Shanthi V Sitaraman
Journal:  Gastroenterology       Date:  2011-06-30       Impact factor: 22.682

7.  The oncogenic roles of Notch1 in astrocytic gliomas in vitro and in vivo.

Authors:  Peng Xu; Mingzhe Qiu; Zhiyong Zhang; Chunsheng Kang; Rongcai Jiang; Zhifan Jia; Guangxiu Wang; Hao Jiang; Peiyu Pu
Journal:  J Neurooncol       Date:  2009-09-22       Impact factor: 4.130

8.  Down-regulation of Notch1 signaling inhibits tumor growth in human hepatocellular carcinoma.

Authors:  Li Ning; Lucy Wentworth; Herbert Chen; Sharon M Weber
Journal:  Am J Transl Res       Date:  2009-07-10       Impact factor: 4.060

9.  KSHV-induced notch components render endothelial and mural cell characteristics and cell survival.

Authors:  Ren Liu; Xiuqing Li; Anil Tulpule; Yue Zhou; Jeffrey S Scehnet; Shaobing Zhang; Jong-Soo Lee; Preet M Chaudhary; Jae Jung; Parkash S Gill
Journal:  Blood       Date:  2009-11-24       Impact factor: 22.113

10.  Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2.

Authors:  Kamaleldin E Elagib; Mang Xiao; Isa M Hussaini; Lorrie L Delehanty; Lisa A Palmer; Frederick K Racke; Michael J Birrer; Shanmugasundaram Ganapathy-Kanniappan; Ganapath Shanmugasundaram; Michael A McDevitt; Adam N Goldfarb
Journal:  Mol Cell Biol       Date:  2004-09       Impact factor: 4.272
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