Literature DB >> 12676329

Factors secreted by human amniotic epithelial cells promote the survival of rat retinal ganglion cells.

Saiko Uchida1, Yasuyuki Suzuki, Makoto Araie, Kenji Kashiwagi, Yasumasa Otori, Norio Sakuragawa.   

Abstract

We evaluated whether factors secreted by human amniotic epithelial cells (HAECs) have the neuroprotective effect on rat retinal ganglion cells (RGCs) purified by immunopanning. After culture in B27 complete medium containing B27 supplement, brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF) and forskolin, the medium was changed to: (1). medium containing N2 supplement and forskolin (N2 basal medium); (2). medium conditioned by HAECs containing N2 supplement and forskolin (HAEC-CM); and (3). N2 basal medium containing several neurotrophic factors. HAEC-CM promoted the RGC survival compared to N2 basal medium. The effect of HAEC-CM was significantly higher than that of BDNF, neurotrophin-3 and CNTF. These results suggest that HAECs may produce unknown neuroprotective factors, suggesting its potential for the treatment of RGC degenerative diseases.

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Year:  2003        PMID： 12676329     DOI： 10.1016/s0304-3940(02)01454-4

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  15 in total

Review 1.  Human Perinatal-Derived Biomaterials.

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2.  Protective effects of ciliary neurotrophic factor on the retinal ganglion cells by injure of hydrogen peroxide.

Authors:  Wen-Jun Wang; Wei Jin; An-Huai Yang; Zhen Chen; Yi-Qiao Xing
Journal:  Int J Ophthalmol       Date:  2018-06-18       Impact factor: 1.779

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4.  Human amniotic epithelial cells as novel feeder layers for promoting ex vivo expansion of limbal epithelial progenitor cells.

Authors:  Ying-Ting Chen; Wei Li; Yasutaka Hayashida; Hua He; Szu-Yu Chen; David Y Tseng; Ahmad Kheirkhah; Scheffer C G Tseng
Journal:  Stem Cells       Date:  2007-05-10       Impact factor: 6.277

Review 5.  Amnion-derived stem cells: in quest of clinical applications.

Authors:  Toshio Miki
Journal:  Stem Cell Res Ther       Date:  2011-05-19       Impact factor: 6.832

6.  Neuroprotective effects of flavonoids on hypoxia-, glutamate-, and oxidative stress-induced retinal ganglion cell death.

Authors:  Mao Nakayama; Makoto Aihara; Yi-Ning Chen; Makoto Araie; Kaori Tomita-Yokotani; Tsukasa Iwashina
Journal:  Mol Vis       Date:  2011-07-02       Impact factor: 2.367

7.  Neuroprotective effect of astaxanthin against rat retinal ganglion cell death under various stresses that induce apoptosis and necrosis.

Authors:  Reiko Yamagishi; Makoto Aihara
Journal:  Mol Vis       Date:  2014-12-31       Impact factor: 2.367

8.  Amniotic epithelial cells from the human placenta potently suppress a mouse model of multiple sclerosis.

Authors:  Yu Han Liu; Vijesh Vaghjiani; Jing Yang Tee; Kelly To; Peng Cui; Ding Yuan Oh; Ursula Manuelpillai; Ban-Hock Toh; James Chan
Journal:  PLoS One       Date:  2012-04-26       Impact factor: 3.240

9.  Amniotic fluid exerts a neurotrophic influence on fetal neurodevelopment via the ERK/GSK-3 pathway.

Authors:  Yongwoo Jang; Eun-Kyung Kim; Won-Sik Shim; Ki-Min Song; Sung Min Kim
Journal:  Biol Res       Date:  2015-08-05       Impact factor: 5.612

10.  Hyperbaric pressure and increased susceptibility to glutamate toxicity in retinal ganglion cells in vitro.

Authors:  Makoto Aihara; Yi-Ning Chen; Saiko Uchida; Mao Nakayama; Makoto Araie
Journal:  Mol Vis       Date:  2014-05-02       Impact factor: 2.367
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