| Literature DB >> 12676105 |
Roland Le Borgne1, François Schweisguth.
Abstract
Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.Entities:
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Year: 2003 PMID: 12676105 DOI: 10.1016/s0960-9822(03)00199-4
Source DB: PubMed Journal: Curr Biol ISSN: 0960-9822 Impact factor: 10.834