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Literature DB >> 12675484

Effects of the beta1-selective adrenergic antagonist betaxolol on electroretinography in the perfused cat eye.

Yukitaka Uji¹, Manami Kuze, Hisashi Matubara, Motoaki Doi, Mikio Sasoh.

Abstract

The effects of the beta1-selective adrenergic antagonist betaxolol on electroretinography (ERG) were studied in the isolated and arterially perfused cat eye. Betaxolol increased the perfusion flow rate, significantly at the administrations of more than 50 microM concentrations and induced a dose-related, reversible increase in the amplitudes of both the a-wave and b-wave of ERG. These results suggest that the calcium-channel blocking mechanism of betaxolol has a beneficial influence on ocular blood flow and retinal electrical activity in response to light. As it is known that ERG is a good indicator of the functional integrity of the retina, this indicates that betaxolol could be an ideal drug for treating glaucoma in which ischemia is involved to some extent.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2003 PMID： 12675484 DOI： 10.1023/a:1022404630736

Source DB: PubMed Journal: Doc Ophthalmol ISSN： 0012-4486 Impact factor: 2.379

14 in total

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