Literature DB >> 1267438

Significant reduction in the incidence of phlebitis with buffered versus unbuffered cephalothin.

M G Bergeron, J L Brusch, M Barza, L Weinstein.   

Abstract

Cephalothin (1 g every 2 h), buffered cephalothin, and diluent alone (5% dextrose in water) were each administered for 4 days intravenously to 12 volunteers in a double-blind crossover study. The incidence of phlebitis with buffered cephalothin was significantly lower than that with unbuffered drug (P < 0.01) and almost identical to the incidence with diluent alone.

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Year:  1976        PMID: 1267438      PMCID: PMC429591          DOI: 10.1128/AAC.9.4.646

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  4 in total

Review 1.  Phlebitis associated with intravenous drug administration.

Authors:  S J Turco
Journal:  Bull Parenter Drug Assoc       Date:  1975 Mar-Apr

2.  Effect of buffering on the incidence and severity of cephalothin-induced phlebitis.

Authors:  A G Lipman
Journal:  Am J Hosp Pharm       Date:  1974-03

3.  Effect of pH in glucose infusions on development of thrombophlebitis.

Authors:  E W Fonkalsrud; J Murphy; F G Smith
Journal:  J Surg Res       Date:  1968-11       Impact factor: 2.192

4.  Double-blind comparison of phlebitis produced by cephalothin infusions with buffered and unbuffered diluents.

Authors:  J Carrizosa; M E Levison; D Kaye
Journal:  Antimicrob Agents Chemother       Date:  1974-02       Impact factor: 5.191

  4 in total
  4 in total

1.  Comparative pharmacokinetics of cefamandole, cephapirin, and cephalothin in healthy subjects and effect of repeated dosing.

Authors:  M Barza; S Melethil; S Berger; E C Ernst
Journal:  Antimicrob Agents Chemother       Date:  1976-09       Impact factor: 5.191

2.  Comparative incidence of phlebitis due to buffered cephalothin, cephapirin, and cefamandole.

Authors:  S Berger; E C Ernst; M Barza
Journal:  Antimicrob Agents Chemother       Date:  1976-04       Impact factor: 5.191

3.  Postinfusion Phlebitis: Incidence and Risk Factors.

Authors:  Joan Webster; Matthew McGrail; Nicole Marsh; Marianne C Wallis; Gillian Ray-Barruel; Claire M Rickard
Journal:  Nurs Res Pract       Date:  2015-05-14

Review 4.  Infusion phlebitis assessment measures: a systematic review.

Authors:  Gillian Ray-Barruel; Denise F Polit; Jenny E Murfield; Claire M Rickard
Journal:  J Eval Clin Pract       Date:  2014-01-08       Impact factor: 2.431

  4 in total

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