| Literature DB >> 12673554 |
Anna Maria Cianciulli1, Costantino Leonardo, Fiorella Guadagni, Raffaella Marzano, Francesco Iori, Cosimo De Nunzio, Giorgio Franco, Roberta Merola, Cesare Laurenti.
Abstract
A systematic analysis of both tumors and the surrounding urothelium to help identify what lies behind the mechanism of multifocal tumor development has not yet been performed. In this study we investigated chromosome 1, 7, 9, and 17 aneusomy in 25 superficial papillary carcinomas and in 51 tissue samples taken from sites of macroscopically uninvolved urothelium surrounding the tumors, using the fluorescence in situ hybridization method. Our data demonstrated a close genetic relationship between all examined tumors and normal-appearing mucosa. Numeric aberrations of chromosomes 1, 7, 9, and 17 were found to exhibit similar patterns in all analyzed specimens, although with different frequencies. Copyright 2003 Elsevier Inc.Entities:
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Year: 2003 PMID： 12673554 DOI： 10.1053/hupa.2003.30
Source DB: PubMed Journal: Hum Pathol ISSN： 0046-8177 Impact factor: 3.466