Literature DB >> 12673044

Synthesis, analgesic and anti-inflammatory activities of some novel 2,3-disubstituted quinazolin-4(3H)-ones.

Veerachamy Alagarsamy1, Veluchamy Muthukumar, Nagendran Pavalarani, Poongavanam Vasanthanathan, Rajappan Revathi.   

Abstract

A series of novel 2-benzylamino-3-substituted quinazolin-4(3H)-ones have been synthesized by treating 3-amino-2-benzylamino quinazolin-4(3H)-one, with different aldehydes and ketones. The starting material 3-amino-2-benzylamino quinazolin-4(3H)-one was synthesized by nucleophilic substitution of thiomethyl group of 3-amino-2-methylthio quinazolin-4(3H)-one by benzylamine. The title compounds were investigated for analgesic and anti-inflammatory activities. All the test compounds exhibited significant analgesic activity, whereas the compound III is equipotent with diclofenac sodium. The compounds I, II and III showed more potent anti-inflammatory activity than diclofenac sodium.

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Year:  2003        PMID： 12673044     DOI： 10.1248/bpb.26.557

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  8 in total

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Journal:  Eur J Med Chem       Date:  2010-08-06       Impact factor: 6.514

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Journal:  Chem Cent J       Date:  2013-06-03       Impact factor: 4.215

7.  Synthesis, SAR Study and Evaluation of Mannich and Schiff Bases of Pyrazol-5(4H)-one Moiety Containing 3-(Hydrazinyl)-2-phenylquinazolin-4(3H)-one.

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Journal:  Indian J Pharm Sci       Date:  2013-07       Impact factor: 0.975

8.  Synthesis, Spectroscopic Characterization, and Time-Dependent DFT Calculations of 1-Methyl-5-phenyl-5H-pyrido[1,2-a]quinazoline-3,6-dione and Its Starting Precursor in Different Solvents.

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Journal:  ChemistryOpen       Date:  2018-10-12       Impact factor: 2.911
  8 in total

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