Literature DB >> 12672599

Preparation and evaluation of ibuprofen beads by melt solidification technique.

Anant R Paradkar1, Manish Maheshwari, Anant R Ketkar, Bhaskar Chauhan.   

Abstract

A novel single step melt solidification technique was developed for ibuprofen. DSC studies designed to elucidate the effect of isothermal holding time showed that the extent of crystallization increased with holding time. Agitation speed and polyvinyl alcohol (PVA) were found to reduce the time required for crystallization. The excipient-free, non-disintegrating beads were irregular in shape with high mechanical strength and acceptable flowability. Slow dissolution from beads was attributed to the compactness and higher bond strength of the beads.

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Year:  2003        PMID： 12672599     DOI： 10.1016/s0378-5173(03)00081-4

Source DB:  PubMed          Journal:  Int J Pharm        ISSN： 0378-5173            Impact factor:   5.875


  14 in total

1.  Preparation and characterization of flurbiprofen beads by melt solidification technique.

Authors:  Anant Paradkar; Manish Maheshwari; Amit Kumar Tyagi; Bhaskar Chauhan; S S Kadam
Journal:  AAPS PharmSciTech       Date:  2003-12-16       Impact factor: 3.246

2.  Study of polymorphs of progesterone by novel melt sonocrystallization technique: a technical note.

Authors:  R Tripathi; Shailesh V Biradar; B Mishra; Anant R Paradkar
Journal:  AAPS PharmSciTech       Date:  2010-09-21       Impact factor: 3.246

3.  Design and evaluation of celecoxib porous particles using melt sonocrystallization.

Authors:  Anant Paradkar; Manish Maheshwari; Ravindra Kamble; Ian Grimsey; Peter York
Journal:  Pharm Res       Date:  2006-06-07       Impact factor: 4.200

4.  Study of particle rearrangement, compression behavior and dissolution properties after melt dispersion of ibuprofen, Avicel and Aerosil.

Authors:  Subrata Mallick; Saroj Kumar Pradhan; Muronia Chandran; Manoj Acharya; Tanmayee Digdarsini; Rajaram Mohapatra
Journal:  Results Pharma Sci       Date:  2011-05-17

5.  Solubility enhancement of rosiglitazone by using melt sonocrystallization technique.

Authors:  Vaibhavkumar A Jagtap; G Vidyasagar; S C Dvivedi
Journal:  J Ultrasound       Date:  2014-02-27

6.  Melt solidification technique: incorporation of higher wax content in ibuprofen beads.

Authors:  Ravindra Kamble; Manish Maheshwari; Anant Paradkar; Shivajirao Kadam
Journal:  AAPS PharmSciTech       Date:  2004-10-08       Impact factor: 3.246

7.  Crystallo-co-agglomeration: a novel technique to obtain ibuprofen-paracetamol agglomerates.

Authors:  Atmaram P Pawar; Anant R Paradkar; Shivajirao S Kadam; Kakasaheb R Mahadik
Journal:  AAPS PharmSciTech       Date:  2004-06-19       Impact factor: 3.246

8.  Agglomeration of Ibuprofen with talc by novel crystallo-co-agglomeration technique.

Authors:  Atmaram Pawar; Anant Paradkar; Shivajirao Kadam; Kakasaheb Mahadik
Journal:  AAPS PharmSciTech       Date:  2004-09-07       Impact factor: 3.246

9.  Ultrasound assisted engineering of lactose crystals.

Authors:  Ravindra S Dhumal; Shailesh V Biradar; Anant R Paradkar; Peter York
Journal:  Pharm Res       Date:  2008-07-01       Impact factor: 4.200

10.  Effects of humidity and surfaces on the melt crystallization of ibuprofen.

Authors:  Dong-Joo Lee; Suyang Lee; Il Won Kim
Journal:  Int J Mol Sci       Date:  2012-08-17       Impact factor: 6.208
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