| Literature DB >> 12672227 |
Laval Chan1, T Jagadeeswar Reddy, Mélanie Proulx, Sanjoy K Das, Oswy Pereira, Wuyi Wang, Arshad Siddiqui, Constantin G Yannopoulos, Carl Poisson, Nathalie Turcotte, Alexandre Drouin, M Hicham Alaoui-Ismaili, Richard Bethell, Martine Hamel, Lucille L'Heureux, Darius Bilimoria, Nghe Nguyen-Ba.
Abstract
The HCV NS5B RNA dependent RNA polymerase plays an essential role in viral replication. The discovery of a novel class of inhibitors based on an N,N-disubstituted phenylalanine scaffold and structure-activity relationships studies to improve potency are described.Entities:
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Year: 2003 PMID： 12672227 DOI： 10.1021/jm0340400
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446