OBJECTIVE: The cohort consisted of 328 very low birth weight infants (600-1250 g birth weight) who were enrolled in the low-dose prophylactic indomethacin prevention trial and were intraventricular hemorrhage (IVH) negative at 6 postnatal hours. The objective was to determine the effects of both IVH and indomethacin on cognitive, language, and achievement performance at 8 years of age. METHODS: The cohort was divided into 4 subgroups for analysis: indomethacin plus IVH, indomethacin no IVH, saline plus IVH, and saline with no IVH. The children were evaluated prospectively at 8 years of age with a neurologic assessment, history of school performance, and a battery of cognitive, academic, behavioral, and functional assessments. RESULTS: Children in both IVH groups had more cerebral palsy; more hearing impairment; lower daily living skills scores; lower IQ, vocabulary, and reading and mathematics achievement test scores; and greater educational resource needs. With logistic regression analyses grade 3 to 4 IVH, periventricular leukomalacia and/or ventriculomegaly, male gender, maternal education, and language spoken in the home contributed to outcomes. No effects of indomethacin or gestational age were identified. CONCLUSIONS: Although biological factors including IVH, ventriculomegaly, and periventricular leukomalacia contribute significantly to school age outcomes among very low birth weight survivors at 8 years of age, social and environmental factors including maternal level of education and primary language spoken in the home are also important contributors to outcome.
RCT Entities:
OBJECTIVE: The cohort consisted of 328 very low birth weight infants (600-1250 g birth weight) who were enrolled in the low-dose prophylactic indomethacin prevention trial and were intraventricular hemorrhage (IVH) negative at 6 postnatal hours. The objective was to determine the effects of both IVH and indomethacin on cognitive, language, and achievement performance at 8 years of age. METHODS: The cohort was divided into 4 subgroups for analysis: indomethacin plus IVH, indomethacin no IVH, saline plus IVH, and saline with no IVH. The children were evaluated prospectively at 8 years of age with a neurologic assessment, history of school performance, and a battery of cognitive, academic, behavioral, and functional assessments. RESULTS:Children in both IVH groups had more cerebral palsy; more hearing impairment; lower daily living skills scores; lower IQ, vocabulary, and reading and mathematics achievement test scores; and greater educational resource needs. With logistic regression analyses grade 3 to 4 IVH, periventricular leukomalacia and/or ventriculomegaly, male gender, maternal education, and language spoken in the home contributed to outcomes. No effects of indomethacin or gestational age were identified. CONCLUSIONS: Although biological factors including IVH, ventriculomegaly, and periventricular leukomalacia contribute significantly to school age outcomes among very low birth weight survivors at 8 years of age, social and environmental factors including maternal level of education and primary language spoken in the home are also important contributors to outcome.
Authors: Katherine M Mullen; Betty R Vohr; Karol H Katz; Karen C Schneider; Cheryl Lacadie; Michelle Hampson; Robert W Makuch; Allan L Reiss; R Todd Constable; Laura R Ment Journal: Neuroimage Date: 2010-11-10 Impact factor: 6.556
Authors: Shelli R Kesler; Laura R Ment; Betty Vohr; Sarah K Pajot; Karen C Schneider; Karol H Katz; Timothy B Ebbitt; Charles C Duncan; Robert W Makuch; Allan L Reiss Journal: Pediatr Neurol Date: 2004-11 Impact factor: 3.372
Authors: Laura R Ment; Shelli Kesler; Betty Vohr; Karol H Katz; Heidi Baumgartner; Karen C Schneider; Susan Delancy; John Silbereis; Charles C Duncan; R Todd Constable; Robert W Makuch; Allan L Reiss Journal: Pediatrics Date: 2009-02 Impact factor: 7.124
Authors: Judith S Mercer; Betty R Vohr; Margaret M McGrath; James F Padbury; Michael Wallach; William Oh Journal: Pediatrics Date: 2006-04 Impact factor: 7.124