| Literature DB >> 12670776 |
Rubin M Tuder1, Sharon McGrath, Enid Neptune.
Abstract
Emphysema results from a multi-step, complex, process of lung destruction. This review aims at organizing the available information concerning the animal models of emphysema as to which step of the pathogenesis they address. The experimental models have been classified as to whether they are based on: (a) pharmacological, (b) environmental, or (c) genetic manipulations to induce emphysema and whether they are: (a) triggers or initiators of emphysema, (b) modifiers of lung predisposition to further damage by trigger factors, or (c) mediators of lung tissue destruction. Copyright 2003 Elsevier Science Ltd.Entities:
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Year: 2003 PMID： 12670776 DOI： 10.1016/S1094-5539(02)00099-8
Source DB: PubMed Journal: Pulm Pharmacol Ther ISSN： 1094-5539 Impact factor: 3.410