Literature DB >> 12670661

Hydroxyl-substituted sulfonylureas as potent inhibitors of specific [3H]glyburide binding to rat brain synaptosomes.

Ronald A Hill1, Sonali Rudra, Bo Peng, David S Roane, Jeffrey K Bounds, Yang Zhang, Ahmad Adloo, Tiansheng Lu.   

Abstract

We are seeking to discover potent CNS-active sulfonylureas with structural features that allow for the formation of several types of prodrugs. We report herein the syntheses of compounds comprising an initial series of hydroxyl-substituted analogues of the potent ATP-sensitive potassium channel blockers glyburide (glibenclamide) and gliquidone. Somewhat unexpectedly, several of the compounds were found to be comparably potent to glyburide as inhibitors of specific [(3)H]glyburide binding in rat brain preparations.

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Year:  2003        PMID： 12670661     DOI： 10.1016/s0968-0896(02)00606-5

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  5 in total

1.  Contributions of human cytochrome P450 enzymes to glyburide metabolism.

Authors:  Lin Zhou; Suresh B Naraharisetti; Li Liu; Honggang Wang; Yvonne S Lin; Nina Isoherranen; Jashvant D Unadkat; Mary F Hebert; Qingcheng Mao
Journal:  Biopharm Drug Dispos       Date:  2010-05       Impact factor: 1.627

2.  Validation of a sensitive LC-MS assay for quantification of glyburide and its metabolite 4-transhydroxy glyburide in plasma and urine: an OPRU Network study.

Authors:  Suresh Babu Naraharisetti; Brian J Kirby; Mary F Hebert; Thomas R Easterling; Jashvant D Unadkat
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2007-10-22       Impact factor: 3.205

3.  Quantitative determination of metformin, glyburide and its metabolites in plasma and urine of pregnant patients by LC-MS/MS.

Authors:  Xing Zhang; Xiaoming Wang; Daria I Vernikovskaya; Valentina M Fokina; Tatiana N Nanovskaya; Gary D V Hankins; Mahmoud S Ahmed
Journal:  Biomed Chromatogr       Date:  2014-08-27       Impact factor: 1.902

4.  Orally bioavailable potent soluble epoxide hydrolase inhibitors.

Authors:  Sung Hee Hwang; Hsing-Ju Tsai; Jun-Yan Liu; Christophe Morisseau; Bruce D Hammock
Journal:  J Med Chem       Date:  2007-07-06       Impact factor: 7.446

5.  Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide.

Authors:  Olga L Zharikova; Valentina M Fokina; Tatiana N Nanovskaya; Ronald A Hill; Donald R Mattison; Gary D V Hankins; Mahmoud S Ahmed
Journal:  Biochem Pharmacol       Date:  2009-08-11       Impact factor: 5.858
  5 in total

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