| Literature DB >> 12670658 |
Corwin Hansch1, Rajni Garg, Alka Kurup, Suresh Babu Mekapati.
Abstract
A study of a very large database of QSAR (9100) has uncovered a few unusual examples where as one increases the hydrophobicity of the members of a set of congeners, activity decreases until at a certain point, activity begins to increase. Obviously a change in mechanism is involved. The only way we have found to rationalize this unusual event is by a change in the structure of the receptor. We have found this to occur with hemoglobin, a substance first used to define allosteric reactions.Mesh：
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Year: 2003 PMID： 12670658 DOI： 10.1016/s0968-0896(03)00056-7
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641