OBJECTIVE: To investigate the associations among depression, smoking behaviour and enumerative measures of immunity in a population-based cohort study. METHODS: Participants in the European Prospective Investigation into Cancer and Nutrition in Norfolk, England, aged 40-80 years, were identified through age-sex general practice registers. After exclusions for prevalent conditions, white blood cell (WBC) counts and a measure of depressive episode history were available from 11,367 participants and, after a mean interval of 44 months, from 11,857 at a second health check. The measure of depression was completed between health checks. RESULTS: Observed associations between leukocyte counts and depression for men were weakened following adjustment for cigarette smoking. There was an incremental elevation in age-smoking adjusted mean WBC count by recency of depression such that there was a 3.1% (P=.03) and 5.6% (P=.0004) difference across depression history subgroups (never, lifetime, current) at the first and second health checks, respectively. No age-smoking adjusted associations were observed for women. CONCLUSION: Following adjustment for age and cigarette smoking, these data provide evidence for an association between major depressive disorder and leukocyte counts for men, but not for women.
OBJECTIVE: To investigate the associations among depression, smoking behaviour and enumerative measures of immunity in a population-based cohort study. METHODS:Participants in the European Prospective Investigation into Cancer and Nutrition in Norfolk, England, aged 40-80 years, were identified through age-sex general practice registers. After exclusions for prevalent conditions, white blood cell (WBC) counts and a measure of depressive episode history were available from 11,367 participants and, after a mean interval of 44 months, from 11,857 at a second health check. The measure of depression was completed between health checks. RESULTS: Observed associations between leukocyte counts and depression for men were weakened following adjustment for cigarette smoking. There was an incremental elevation in age-smoking adjusted mean WBC count by recency of depression such that there was a 3.1% (P=.03) and 5.6% (P=.0004) difference across depression history subgroups (never, lifetime, current) at the first and second health checks, respectively. No age-smoking adjusted associations were observed for women. CONCLUSION: Following adjustment for age and cigarette smoking, these data provide evidence for an association between major depressive disorder and leukocyte counts for men, but not for women.
Authors: M A Beydoun; H A Beydoun; G A Dore; J-A Canas; M T Fanelli-Kuczmarski; M K Evans; A B Zonderman Journal: Transl Psychiatry Date: 2016-09-20 Impact factor: 6.222
Authors: Mareike Ernst; Elmar Brähler; Daniëlle Otten; Antonia M Werner; Ana N Tibubos; Iris Reiner; Felix Wicke; Jörg Wiltink; Matthias Michal; Markus Nagler; Thomas Münzel; Philipp S Wild; Jochem König; Norbert Pfeiffer; Andreas Borta; Karl J Lackner; Manfred E Beutel Journal: Sci Rep Date: 2021-01-26 Impact factor: 4.379