| Literature DB >> 12670223 |
Charlene C K Keh1, Chunmei Wei, Chao-Jun Li.
Abstract
The aqueous Barbier-Grignard-type alkylation of aldehydes with unactivated alkyl iodides and bromides was developed. By using a combination of zinc and cuprous iodide, catalyzed by indium(I) chloride, we successfully added tertiary, secondary, and primary alkyl halides to various aromatic aldehydes in 0.07 M aqueous Na2C2O4. A mechanistic rationale for the success of the reaction has been proposed.Entities:
Year: 2003 PMID： 12670223 DOI： 10.1021/ja029649p
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419