Literature DB >> 12670046

Core structure in roselipins essential for eliciting inhibitory activity against diacylglycerol acyltransferase.

Hiroshi Tomoda1, Noriko Tabata, Yukako Ohyama, Satoshi Omura.   

Abstract

Fungal roselipins, discovered as inhibitors of diacylglycerol acyltransferase (DGAT), consist of three parts; highly methylated C20 fatty acid, mannose and arabinitol. Demannosyl and/or dearabinitoyl roselipins were prepared chemically or enzymatically. Demannnosyl roselipins conserved the DGAT inhibitory activity, but the others lost the activity, indicating that the arabinitoyl fatty acid core is essential for eliciting the activity.

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Year:  2003        PMID： 12670046     DOI： 10.7164/antibiotics.56.24

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  3 in total

1.  Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites.

Authors:  Sheo B Singh; Hiranthi Jayasuriya; Raymond Dewey; Jon D Polishook; Anne W Dombrowski; Deborah L Zink; Ziqiang Guan; Javier Collado; Gonzalo Platas; Fernando Pelaez; Peter J Felock; Daria J Hazuda
Journal:  J Ind Microbiol Biotechnol       Date:  2004-01-09       Impact factor: 3.346

Review 2.  Chemistry and Biology of Bioactive Glycolipids of Marine Origin.

Authors:  Iván Cheng-Sánchez; Francisco Sarabia
Journal:  Mar Drugs       Date:  2018-08-22       Impact factor: 5.118

3.  Polyketide glycosides from Bionectria ochroleuca inhibit Candida albicans biofilm formation.

Authors:  Bin Wang; Jianlan You; Jarrod B King; Shengxin Cai; Elizabeth Park; Douglas R Powell; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2014-10-10       Impact factor: 4.050
  3 in total

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