| Literature DB >> 12669257 |
Y-P Kim1, H-B Kim, M-H Jang, B-V Lim, Y-J Kim, H Kim, S-S Kim, E-H Kim, C-J Kim.
Abstract
The effect of treadmill exercise on cell proliferation in the dentate gyrus was studied in Sprague-Dawley rats via 5-bromo-2'-deoxyuridine (BrdU)-specific immunohistochemistry. For studying the dependence of this effect on the magnitude of exercise, animals were divided into the control, light-exercise, moderate-exercise, and severe-exercise groups; different exercise regimens were applied to the groups. To study the temporal dependence of this effect, animals were divided into the control, 1-day-exercise, 3-days-exercise, 7-days-exercise, 14-days-exercise, and 28-days-exercise groups; the regimen used on the light-exercise group was applied to each of the exercise group over the respective number of days. Cell proliferation was most prominent in the light-exercise group (p < 0.001) and reached a maximum level after 7 days of exercise (p < 0.001). In this study, it was shown that cell proliferation is modulated by the intensity and duration of treadmill exercise.Entities:
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Year: 2003 PMID： 12669257 DOI： 10.1055/s-2003-38202
Source DB: PubMed Journal: Int J Sports Med ISSN： 0172-4622 Impact factor: 3.118