| Literature DB >> 12668921 |
Victor Dishy1, Simi Gupta, Ruth Landau, Hong-Guang Xie, Richard B Kim, Richard M Smiley, Daniel W Byrne, Alastair J J Wood, C Michael Stein.
Abstract
A common polymorphism (C825T) of the gene encoding the G-protein beta(3) subunit has been associated with obesity. We examined the hypothesis that this polymorphism affected weight gain during pregnancy. Two hundred and ninety-four women with uncomplicated term deliveries of singleton pregnancies were genotyped. Women homozygous for the T allele (TT) gained significantly more weight than women carrying the C allele (CC and CT groups) (P = 0.006) and had a significantly higher pre-pregnancy body mass index (P = 0.02). The C825T polymorphism of the G-protein beta(3) subunit gene, known to be associated with obesity, is a determinant of weight gain during pregnancy.Entities:
Mesh：
Substances：
Year: 2003 PMID： 12668921 DOI： 10.1097/00008571-200304000-00009
Source DB: PubMed Journal: Pharmacogenetics ISSN： 0960-314X