Literature DB >> 12668806

Successful treatment of empyema thoracis with human recombinant deoxyribonuclease.

G Simpson1, D Roomes, B Reeves.   

Abstract

Fibrinolytic enzymes, particularly streptokinase, are now widely used to treat empyema thoracis. Recent in vitro evidence suggests that streptokinase has no effect on pus viscosity but that deoxyribonuclease (DNase) reduces the viscosity of pus. We report the first use of human recombinant DNase given intrapleurally to treat an empyema which had not resolved after standard treatment with streptokinase.

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Year:  2003        PMID： 12668806      PMCID： PMC1746626          DOI： 10.1136/thorax.58.4.365

Source DB:  PubMed          Journal:  Thorax        ISSN： 0040-6376            Impact factor:   9.139


  9 in total

Review 1.  Intrapleural tissue plasminogen activator and deoxyribonuclease therapy for pleural infection.

Authors:  Francesco Piccolo; Natalia Popowicz; Donny Wong; Yun Chor Gary Lee
Journal:  J Thorac Dis       Date:  2015-06       Impact factor: 2.895

2.  Dornase Alfa Ototoxic Effects in Animals and Efficacy in the Treatment of Clogged Tympanostomy Tubes in Children: A Preclinical Study and a Randomized Clinical Trial.

Authors:  Kenny H Chan; Gregory C Allen; Peggy E Kelley; Sven-Olrik Streubel; Norman R Friedman; Patricia Yoon; Dexiang Gao; Amanda G Ruiz; Timothy T K Jung
Journal:  JAMA Otolaryngol Head Neck Surg       Date:  2018-09-01       Impact factor: 6.223

3.  Empyema thoracis.

Authors:  Ala Eldin H Ahmed; Tariq E Yacoub
Journal:  Clin Med Insights Circ Respir Pulm Med       Date:  2010-06-17

4.  Intrapleural administration of DNase alone for pleural empyema.

Authors:  Vladimir Bobek; Andrzej Majewski; Katarina Kolostova; Adam Rzechonek; Robert Lischke; Jan Schutzner; Grzegorz Kacprzak
Journal:  Int J Clin Exp Med       Date:  2015-11-15

5.  Intrapleural therapy in management of complicated parapneumonic effusions and empyema.

Authors:  Alaeldin H Ahmed; Tariq E Yacoub
Journal:  Clin Pharmacol       Date:  2010-11-22

6.  Two sequential tPA/DNase courses for noncommunicating loculated collections in pleural infection.

Authors:  Natalia Popowicz; Francesco Piccolo; Ranjan Shrestha; Y C Gary Lee
Journal:  Respirol Case Rep       Date:  2014-05-04

7.  Unintentional intramuscular administration of tPA/DNase for pleural infection.

Authors:  Natalia Popowicz; Michael Nash; Y C Gary Lee
Journal:  Respirol Case Rep       Date:  2014-10-10

8.  Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): a study protocol for a randomized controlled trial.

Authors:  Michael H Livingston; Sanjay Mahant; Felix Ratjen; Bairbre L Connolly; Kevin Thorpe; Muhammad Mamdani; Ian Maclusky; Sophie Laberge; Lucy Giglia; J Mark Walton; Connie L Yang; Ashley Roberts; Anna C Shawyer; Mary Brindle; Simon J Parsons; Cristina A Stoian; Eyal Cohen
Journal:  Trials       Date:  2017-06-24       Impact factor: 2.279

9.  New therapy of pleural empyema by deoxyribonuclease.

Authors:  Grzegorz Kacprzak; Andrzej Majewski; Jerzy Kolodziej; Adam Rzechonek; Robert Gürlich; Vladimir Bobek
Journal:  Braz J Infect Dis       Date:  2013-01-16       Impact factor: 3.257
  9 in total

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