Literature DB >> 12668695

Structure, functions, and activities of a research support informatics section.

Michael D Murray1, Faye E Smith, Joanne Fox, Evgenia Y Teal, Joseph G Kesterson, Troy A Stiffler, Roberta J Ambuehl, Jane Wang, Maria Dibble, Dennis O Benge, Leonard J Betley, William M Tierney, Clement J McDonald.   

Abstract

The authors describe a research group that supports the needs of investigators seeking data from an electronic medical record system. Since its creation in 1972, the Regenstrief Medical Records System has captured and stored more than 350 million discrete coded observations on two million patients. This repository has become a central data source for prospective and retrospective research. It is accessed by six data analysts--working closely with the institutional review board--who provide investigators with timely and accurate data while protecting patient and provider privacy and confidentiality. From January 1, 1999, to July 31, 2002, data analysts tracked their activities involving 47,559 hours of work predominantly for physicians (54%). While data retrieval (36%) and analysis (25%) were primary activities, data analysts also actively collaborated with researchers. Primary objectives of data provided to investigators were to address disease-specific (35.4%) and drug-related (12.2%) questions, support guideline implementation (13.1%), and probe various aspects of clinical epidemiology (5.7%). Outcomes of these endeavors included 117 grants (including 300,000 US dollars per year salary support for data analysts) and 139 papers in peer-reviewed journals by investigators who rated the support provided by data analysts as extremely valuable.

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Year:  2003        PMID: 12668695      PMCID: PMC181990          DOI: 10.1197/jamia.M1252

Source DB:  PubMed          Journal:  J Am Med Inform Assoc        ISSN: 1067-5027            Impact factor:   4.497


  25 in total

Review 1.  Medical record confidentiality law, scientific research, and data collection in the information age.

Authors:  R C Turkington
Journal:  J Law Med Ethics       Date:  1997 Summer-Fall       Impact factor: 1.718

2.  Three decades of research on computer applications in health care: medical informatics support at the Agency for Healthcare Research and Quality.

Authors:  J Michael Fitzmaurice; Karen Adams; John M Eisenberg
Journal:  J Am Med Inform Assoc       Date:  2002 Mar-Apr       Impact factor: 4.497

Review 3.  Practice databases and their uses in clinical research.

Authors:  W M Tierney; C J McDonald
Journal:  Stat Med       Date:  1991-04       Impact factor: 2.373

4.  The use of propensity scores in pharmacoepidemiologic research.

Authors:  S M Perkins; W Tu; M G Underhill; X H Zhou; M D Murray
Journal:  Pharmacoepidemiol Drug Saf       Date:  2000-03       Impact factor: 2.890

5.  Research uses of computer-stored practice records in general medicine.

Authors:  C J McDonald; W M Tierney
Journal:  J Gen Intern Med       Date:  1986 Jul-Aug       Impact factor: 5.128

Review 6.  Computer-stored medical records. Their future role in medical practice.

Authors:  C J McDonald; W M Tierney
Journal:  JAMA       Date:  1988-06-17       Impact factor: 56.272

7.  Data base management, feedback control, and the Regenstrief Medical Record.

Authors:  C McDonald; L Blevins; T Glazener; J Haas; L Lemmon; J Meeks-Johnson
Journal:  J Med Syst       Date:  1983-04       Impact factor: 4.460

8.  Closing the loop between clinical practice, research, and education: the potential of electronic patient records.

Authors:  J van der Lei
Journal:  Methods Inf Med       Date:  2002       Impact factor: 2.176

Review 9.  Renal toxicity of the nonsteroidal anti-inflammatory drugs.

Authors:  M D Murray; D C Brater
Journal:  Annu Rev Pharmacol Toxicol       Date:  1993       Impact factor: 13.820

10.  Ibuprofen-associated renal impairment in a large general internal medicine practice.

Authors:  M D Murray; D C Brater; W M Tierney; S L Hui; C J McDonald
Journal:  Am J Med Sci       Date:  1990-04       Impact factor: 2.378

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  8 in total

1.  Research strategies that result in optimal data collection from the patient medical record.

Authors:  Katherine E Gregory; Lucy Radovinsky
Journal:  Appl Nurs Res       Date:  2010-04-09       Impact factor: 2.257

2.  Implementing Single Source: the STARBRITE proof-of-concept study.

Authors:  Rebecca Kush; Liora Alschuler; Roberto Ruggeri; Sally Cassells; Nitin Gupta; Landen Bain; Karen Claise; Monica Shah; Meredith Nahm
Journal:  J Am Med Inform Assoc       Date:  2007-06-28       Impact factor: 4.497

3.  Electronic Healthcare Record and clinical research in cardiovascular radiology. HL7 CDA and CDISC ODM interoperability.

Authors:  A El Fadly; C Daniel; C Bousquet; T Dart; P-Y Lastic; P Degoulet
Journal:  AMIA Annu Symp Proc       Date:  2007-10-11

4.  Association between adherence measurements of metoprolol and health care utilization in older patients with heart failure.

Authors:  Wanzhu Tu; Andrew B Morris; Jingjin Li; Jingwei Wu; James Young; D Craig Brater; Michael D Murray
Journal:  Clin Pharmacol Ther       Date:  2005-03       Impact factor: 6.875

5.  Risk of hyperkalemia associated with selective COX-2 inhibitors.

Authors:  Hisham Aljadhey; Wanzhu Tu; Richard A Hansen; Susan Blalock; D Craig Brater; Michael D Murray
Journal:  Pharmacoepidemiol Drug Saf       Date:  2010-11       Impact factor: 2.890

6.  The association between nonsteroidal anti-inflammatory drugs and potassium concentrations: A pharmacoepidemiological study in Saudi Arabia.

Authors:  Hisham Aljadhey
Journal:  Saudi Pharm J       Date:  2011-08-23       Impact factor: 4.330

7.  PROTEMPA: a method for specifying and identifying temporal sequences in retrospective data for patient selection.

Authors:  Andrew R Post; James H Harrison
Journal:  J Am Med Inform Assoc       Date:  2007-06-28       Impact factor: 4.497

8.  Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension.

Authors:  Hisham Aljadhey; Wanzhu Tu; Richard A Hansen; Susan J Blalock; D Craig Brater; Michael D Murray
Journal:  BMC Cardiovasc Disord       Date:  2012-10-24       Impact factor: 2.298

  8 in total

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