| Literature DB >> 12668064 |
Henry Klassen1, Karen L Imfeld, Jasodhara Ray, Michael J Young, Fred H Gage, Monique A Berman.
Abstract
Adult hippocampal progenitor cells (AHPCs) derived from mature rats were studied in mixed co-cultures and shown not to elicit a proliferative response from human peripheral blood mononuclear cells (PBMCs) or allogeneic spleen cells. FACS analysis revealed low class I and no detectable class II (Ia) MHC expression by these cells. RT-PCR showed that AHPCs express the anti-inflammatory cytokine TGF-beta1. AHPCs did not, however, significantly impede the proliferation of OKT3- or PHA-stimulated PBMCs. Taken together, these results indicate that AHPCs are non-immunogenic in vitro. This is consistent with their pattern of MHC expression and does not require an active immunosuppressive mechanism.Entities:
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Year: 2003 PMID： 12668064 DOI： 10.1016/s0042-6989(03)00094-4
Source DB: PubMed Journal: Vision Res ISSN： 0042-6989 Impact factor: 1.886