Literature DB >> 12668060

Pseudotyped AAV vectors for constitutive and regulated gene expression in the eye.

Alberto Auricchio1.   

Abstract

Since the first reports describing the injection of recombinant adeno-associated viral (AAV) vectors in the murine eye, the advancement of the field has been enormous resulting in the correction of several animal models of retinal diseases. The recent development of "pseudotyped" AAV vectors with transduction characteristics that best fit the correction of specific retinal disease phenotypes and of sophisticated systems for tight regulation of gene expression expands on the potentiality of this delivery system for the eye.

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Year:  2003        PMID： 12668060     DOI： 10.1016/s0042-6989(02)00676-4

Source DB:  PubMed          Journal:  Vision Res        ISSN： 0042-6989            Impact factor:   1.886


  12 in total

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