| Literature DB >> 12668020 |
Bruce Tomczuk1, Tianbao Lu, Richard M Soll, Cynthia Fedde, Aihua Wang, Larry Murphy, Carl Crysler, Malini Dasgupta, Stephen Eisennagel, John Spurlino, Roger Bone.
Abstract
Although thrombin has been extensively researched with many examples of potent and selective inhibitors, the key characteristics of oral bioavailability and long half-life have been elusive. We report here a novel series non-peptidic phenyl-based, highly potent, highly selective and orally bioavailable thrombin inhibitors using oxyguanidines as guanidine-mimetics.Entities:
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Year: 2003 PMID： 12668020 DOI： 10.1016/s0960-894x(03)00125-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823