Literature DB >> 12668010

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.

Imre Schlemminger1, David R Mole, Luke A McNeill, Anupma Dhanda, Kirsty S Hewitson, Ya-Min Tian, Peter J Ratcliffe, Christopher W Pugh, Christopher J Schofield.   

Abstract

Analogues of the naturally occurring cyclic hydroxamate dealanylalahopcin, which is an inhibitor of procollagen prolyl-4-hydroxylase, were synthesised and shown to be inhibitors of the human hypoxia-inducible factor prolyl hydroxylases.

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Year:  2003        PMID： 12668010     DOI： 10.1016/s0960-894x(03)00149-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  20 in total

1.  Metabolic regulation of intestinal epithelial barrier during inflammation.

Authors:  Sean P Colgan; Valerie F Curtis; Jordi M Lanis; Louise E Glover
Journal:  Tissue Barriers       Date:  2015-04-03

2.  Nitrenium ion azaspirocyclization-spirodienone cleavage: a new synthetic strategy for the stereocontrolled preparation of highly substituted lactams and N-hydroxy lactams.

Authors:  Duncan J Wardrop; Matthew S Burge
Journal:  J Org Chem       Date:  2005-12-09       Impact factor: 4.354

Review 3.  Cellular oxygen sensing in health and disease.

Authors:  David R Mole; Peter J Ratcliffe
Journal:  Pediatr Nephrol       Date:  2007-10-23       Impact factor: 3.714

Review 4.  Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress.

Authors:  Ambreena Siddiq; Leila R Aminova; Rajiv R Ratan
Journal:  Neurochem Res       Date:  2007-03-07       Impact factor: 3.996

Review 5.  Hypoxia: an alarm signal during intestinal inflammation.

Authors:  Sean P Colgan; Cormac T Taylor
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2010-04-06       Impact factor: 46.802

Review 6.  Metabolic shifts in immunity and inflammation.

Authors:  Douglas J Kominsky; Eric L Campbell; Sean P Colgan
Journal:  J Immunol       Date:  2010-04-15       Impact factor: 5.422

7.  Targeting Hypoxia to Augment Mucosal Barrier Function.

Authors:  Caleb J Kelly; Sean P Colgan
Journal:  J Epithel Biol Pharmacol       Date:  2012-01-16

Review 8.  Hypoxia and Mucosal Inflammation.

Authors:  Sean P Colgan; Eric L Campbell; Douglas J Kominsky
Journal:  Annu Rev Pathol       Date:  2016-05-23       Impact factor: 23.472

9.  Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy.

Authors:  Jonathan E Sears; George Hoppe; Quteba Ebrahem; Bela Anand-Apte
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-04       Impact factor: 11.205

10.  Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.

Authors:  Malgorzata Milkiewicz; Christopher W Pugh; Stuart Egginton
Journal:  J Physiol       Date:  2004-08-19       Impact factor: 5.182
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