| Literature DB >> 12668009 |
P Douglas Boatman1, Jan Urban, Minh Nguyen, Maher Qabar, Michael Kahn.
Abstract
A novel alpha-addition of propiolates to urazoles followed by Michael addition of a variety of nucleophiles has been developed for rapid production and optimization of peptidomimetic drug leads. This technology has produced a number of highly potent and selective inhibitors of the serine protease, thrombin.Entities:
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Year: 2003 PMID： 12668009 DOI： 10.1016/s0960-894x(03)00155-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823