Literature DB >> 12668007

Novel openers of Ca2+-dependent large-conductance potassium channels: symmetrical pharmacophore and electrophysiological evaluation of bisphenols.

Yi Li1, Graham Johnson, Jeffrey L Romine, Nicholas A Meanwell, Scott W Martin, Steven I Dworetzky, Christopher G Boissard, Valentin K Gribkoff, John E Starrett.   

Abstract

Electrophysiological evaluation of symmetrical analogues of the known maxi-K opener NS-004 (1) led to the discovery of bisphenols 2a, 3a and 4a as openers of cloned maxi-K channels expressed in oocytes.

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Year:  2003        PMID： 12668007     DOI： 10.1016/s0960-894x(03)00156-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels.

Authors:  Vincenzo Calderone; Silvio Chericoni; Cinzia Martinelli; Lara Testai; Antonio Nardi; Ivano Morelli; Maria Cristina Breschi; Enrica Martinotti
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-09-17       Impact factor: 3.000

Review 2.  Vasodilator compounds derived from plants and their mechanisms of action.

Authors:  Francisco J Luna-Vázquez; César Ibarra-Alvarado; Alejandra Rojas-Molina; Isela Rojas-Molina; Miguel Angel Zavala-Sánchez
Journal:  Molecules       Date:  2013-05-17       Impact factor: 4.411
  2 in total

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