| Literature DB >> 12668002 |
Charles L Cywin1, Bao-Ping Zhao, Daniel W McNeil, Matt Hrapchak, Anthony S Prokopowicz, Daniel R Goldberg, Tina M Morwick, Amy Gao, Scott Jakes, Mohammed Kashem, Ronald L Magolda, Richard M Soll, Mark R Player, Mark A Bobko, James Rinker, Renee L DesJarlais, Michael P Winters.
Abstract
The discovery of novel 5,7-disubstituted[1,6]naphthyridines as potent inhibitors of Spleen Tyrosine Kinase (SYK) is discussed. The SAR reveals the necessity for a 7-aryl group with preference towards para substitution and that this in combination with 5-aminoalkylamino substituents further improved the potency of the compounds. The initial SAR as well as a survey of the other positions is discussed in detail.Entities:
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Year: 2003 PMID： 12668002 DOI： 10.1016/s0960-894x(03)00163-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823