| Literature DB >> 12667999 |
Andriy Mokhir1, Roman Stiebing, Roland Kraemer.
Abstract
Conjugates of peptide nucleic acids (PNA) and metal binding ligands were prepared using solid-phase synthesis. Stability of duplexes of bis-picolylamine-PNA conjugates and DNA was found to be modulated by equimolar concentrations of bioavailable metal ions: Ni(2+), Zn(2+)>Cu(2+). Sequence specificity of PNA was not compromised in the presence of these metal ions.Entities:
Mesh：
Substances：
Year: 2003 PMID： 12667999 DOI： 10.1016/s0960-894x(03)00175-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823