Literature DB >> 12667439

p53 and apoptosis: it's not just in the nucleus anymore.

James J Manfredi1.   

Abstract

The tumor suppressor p53 triggers apoptosis in response to a variety of stress stimuli. Its role as a transcription factor modulating gene expression has been clearly implicated in this process. Two recent publications now argue for an additional direct role of p53 at the mitochondria in inducing apoptosis.

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Year:  2003        PMID： 12667439     DOI： 10.1016/s1097-2765(03)00106-0

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  20 in total

1.  Activation and involvement of p53 in cisplatin-induced nephrotoxicity.

Authors:  Qingqing Wei; Guie Dong; Tianxin Yang; Judit Megyesi; Peter M Price; Zheng Dong
Journal:  Am J Physiol Renal Physiol       Date:  2007-08-01

2.  Bcl2's flexible loop domain regulates p53 binding and survival.

Authors:  Xingming Deng; Fengqin Gao; Tammy Flagg; Jessica Anderson; W Stratford May
Journal:  Mol Cell Biol       Date:  2006-06       Impact factor: 4.272

3.  Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants.

Authors:  Samuel A Danziger; S Joshua Swamidass; Jue Zeng; Lawrence R Dearth; Qiang Lu; Jonathan H Chen; Jianlin Cheng; Vinh P Hoang; Hiroto Saigo; Ray Luo; Pierre Baldi; Rainer K Brachmann; Richard H Lathrop
Journal:  IEEE/ACM Trans Comput Biol Bioinform       Date:  2006 Apr-Jun       Impact factor: 3.710

4.  MSL2 promotes Mdm2-independent cytoplasmic localization of p53.

Authors:  Jan-Philipp Kruse; Wei Gu
Journal:  J Biol Chem       Date:  2008-11-25       Impact factor: 5.157

5.  Loss of Wip1 sensitizes cells to stress- and DNA damage-induced apoptosis.

Authors:  Yun Xia; Pat Ongusaha; Sam W Lee; Yih-Cherng Liou
Journal:  J Biol Chem       Date:  2009-04-24       Impact factor: 5.157

Review 6.  The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.

Authors:  James J Manfredi
Journal:  Genes Dev       Date:  2010-08-01       Impact factor: 11.361

7.  YPEL3, a p53-regulated gene that induces cellular senescence.

Authors:  Kevin D Kelley; Kelly R Miller; Amber Todd; Amy R Kelley; Rebecca Tuttle; Steven J Berberich
Journal:  Cancer Res       Date:  2010-04-13       Impact factor: 12.701

8.  p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug.

Authors:  Shu-Ping Wang; Wen-Lung Wang; Yih-Leong Chang; Chen-Tu Wu; Yu-Chih Chao; Shih-Han Kao; Ang Yuan; Chung-Wu Lin; Shuenn-Chen Yang; Wing-Kai Chan; Ker-Chau Li; Tse-Ming Hong; Pan-Chyr Yang
Journal:  Nat Cell Biol       Date:  2009-05-17       Impact factor: 28.824

9.  Blocking mitochondrial permeability transition prevents p53 mitochondrial translocation during skin tumor promotion.

Authors:  Jianfeng Liu; Daret K St Clair; Xin Gu; Yunfeng Zhao
Journal:  FEBS Lett       Date:  2008-03-20       Impact factor: 4.124

10.  Ceramide and glutathione define two independently regulated pathways of cell death initiated by p53 in Molt-4 leukaemia cells.

Authors:  Wissal El-Assaad; Lina Kozhaya; Sawsan Araysi; Shoghag Panjarian; Fadi F Bitar; Elizabeth Baz; Marwan E El-Sabban; Ghassan S Dbaibo
Journal:  Biochem J       Date:  2003-12-15       Impact factor: 3.857
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